Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD
activity in response to stress.
harveyi, where the MnSOD
gene is up-regulated in hemocytes.
Polymorphic variations in manganese superoxide dismutase (MnSOD
), glutathione peroxidase-1(GPX1), and catalase (CAT) contribute to elevated plasma triglyceride levels in Chinese patients with type 2 diabetes or diabetic cardiovascular disease.
Also, the antioxidant MnSOD
neutralizes superoxide anions generated by cytokine TNF-[alpha] (Agarwal et al., 2005).
Oznaczanie aktywnosci dysmutazy ponadtlenkowej calkowitej (t-SOD) oraz jej izoenzymow mitochondrialnego (MnSOD
) i cytoplazmatycznego (CuZnSOD) (EC 22.214.171.124)
In recent years many studies were published in the literature that address structures like GLUTI GLUT3, HIF1, TBX, manganese-dependent superoxide dismutase (MnSOD
), glutathione peroxidase 1 (GPxl), catalase C-262T polymorphism (CAT262), and the correlation between their polymorphisms and other types of cancers.
Particulate phase cigarette smoke increases MnSOD
, NQO1, and CINC-1 in rat lungs.
Alpha Mangostin Upregulates Antioxidant Defenses mRNA Expressions, MnSOD
In myocardial tissue, SIRT3 localizes to mitochondria , reduces levels of reactive oxygen species (ROS), and blocks cardiac hypertrophic response through activation of Foxo-dependent antioxidants, manganese superoxide dismutase (MnSOD
), and catalase .
Epstein, "Protection of cardiac mitochondria by overexpression of MnSOD
reduces diabetic cardiomyopathy," Diabetes, vol.
Among the endogenous antioxidants, manganese superoxide dismutase (MnSOD
) is one of the critical enzymes which defends against ROS in the mitochondria.
Sirtuin 3 protects the heart against oxidative stress from the activation of the family of transcription factors O3a (FoxO3a) that augment the transcription of the gene codifiers for antioxidants like the manganese superoxide dismutase (MnSOD
) and the catalase [58, 81].