The aim of the present study was to elucidate the mechanism by which hyperthermia applied through a hot-water bag induces subcellular destructive changes including MMTV in the spontaneous mammary tumors in the Strong A inbred strain of mice.
Some of the most intriguing hints of an infectious cause in humans come from how the basic geography of the disease syncs with prevalence of MMTV. A woman's odds of getting breast cancer greatly depend on where she lives.
Similarly mouse mammary tumour virus (MMTV) has been found to cause breast cancer in mice, and it has been shown that the virus could infect breast cells in humans (Retrovirology, DOI:10.1186/1742-4690, vol.4,p 73).
Holland and his colleagues named human mammary tumor virus (HMTV) several years ago has been shown to be 95% genetically identical to the mouse mammary tumor virus (MMTV), which is highly prevalent in Mas domesticus, the common house mouse that has lived closely with humans since the dawn of agriculture.