These include extending the Human Papillomavirus (HPV) vaccine to boys, the new combined MMRV
vaccine, and a replacement pneumococcal vaccine.
Comparing MMRV with MMR + V found no increased risk of seven main neurological, blood or immune system disorders (immune thrombocytopenia purpura, anaphylaxis, ataxia, arthritis, meningitis/encephalitis, acute disseminated encephalomyelitis and Kawasaki disease).
This study did not identify any new safety concerns comparing MMRV with MMR + V or after either the MMRV or the MMR + V vaccine," said lead author Nicola P.
The study also confirmed the findings from previous studies that MMRV and MMR + V are associated with fever and febrile seizure seven to 10 days after vaccination among 1-year-old children, and that MMRV versus MMR + V is associated with an increased risk of seizures during that interval.
Our findings offer reassurance that adverse outcomes of measles-containing vaccines are extremely rare and unlikely, and that parents of 1-year-old children can choose MMR + V instead of MMRV vaccines to reduce the low risk of fever and febrile seizures.
Among 1-2 year olds, the risk of febrile seizures 7-10 days after MMRV was double that of separate MMR+V.
The results provide reassuring evidence that neither MMRV, nor MMR plus V, appear to be associated with an increased risk of post-vaccination febrile seizures in this 4-6 age group," said Dr.
As febrile seizures are generally much less likely to occur among 4- to 6-year-old children, it is not surprising that we did not detect increased febrile seizures following MMRV or MMR plus V among 4- to 6-year-old children," Dr.
Because the risk of febrile seizure is higher for the quadrivalent (combination) vaccine, providers recommending MMRV should communicate to parents that it increases the risk of fever and febrile seizure over that already associated with measles-containing vaccines," said the study's lead investigator Nicola Klein, MD, Ph.
The CDC recently recommended that either vaccine may be used for first dose for 1-2 year olds, however families without a strong preference for MMRV should receive separate MMR +V vaccines, Klein said.
Kaiser Permanente researchers used its electronic health records and Vaccine Safety Datalink data from 2000 to 2008 to assess seizures and fever visits among children aged 12-23 months following MMRV and separate MMR +V.