MMP9


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MMP9

A gene on chromosome 20q12-q13 that encodes matrix metalloproteinase 9, which degrades collagens IV and V, gelatins I and V, and fibronectin. It is thought to play a key role in local proteolysis of the extracellular matrix and in leukocyte migration, and may play a role in osteoclastic resorption of bone.

Molecular pathology
Defects in MMP9 increase susceptibility to intervertebral disc disease and lumbar disc herniation; MMP9 defects cause metaphyseal anadysplasia type 2.
References in periodicals archive ?
Expressions of cell metastasis-related proteins, E-cadherin, MMP2, and MMP9 were analyzed by western blot.
However, this finding was not confirmed by a prospective study in Bangladesh: In that study, no overall associations between As exposure and MMP-9 were observed, but slight decreases were found in MMP9 levels at moderate urinary As concentrations, suggesting a possible nonmonotonic relationship (Wu et al.
MiR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14.
95) There is a particularly high level of MMP7 and MMP9 associated with prostate cancer compounds that correlate with a higher Gleason's score.
TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model.
Other oncology pipeline assets include: Andecaliximab, an MMP9 inhibitor currently in Phase III trials in gastric cancer, entospletinib, a SYK inhibitor in Phase II in acute myeloid leukemia, and hematopoietic and lymphoid malignancies; and tirabrutinib, a BTK inhibitor in Phase II for B-cell malignancies, as well as couple candidates in early development.
In situ gene expression and localization of MMP1, MMP2, MMP3, MMP9 and their inhibitors TIMP1 and TIMP2 in human renal cel carcinoma.
Schwalbach, Germany) according to the manufacturer's instructions to detect: epidermal growth factor (EGF), growth related oncogene alpha (GROA), interleukin(IL-)6, IL8, macrophage inflammatory protein 3A, MMP1, MMP9, soluble intercellular adhesion molecule (sICAM)1, tissue inhibitor of metalloproteinase (TIMP)1, tumor necrosis factor alpha (TNFA), and vascular endothelial growth factor alpha (VEGFA).
One study conducted by Isisag et al in 2003 showed no correlation between expression of MMP9 and TIMP-1 and Gleason's score in 43 prostate cancer patients
Naringin, another citrus flavone, suppresses MMP9 expression and AKT phosphorylation leading to reduced migration of TNF-[alpha]-treated VSMCs (Lee et al.