MMP9


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MMP9

A gene on chromosome 20q12-q13 that encodes matrix metalloproteinase 9, which degrades collagens IV and V, gelatins I and V, and fibronectin. It is thought to play a key role in local proteolysis of the extracellular matrix and in leukocyte migration, and may play a role in osteoclastic resorption of bone.

Molecular pathology
Defects in MMP9 increase susceptibility to intervertebral disc disease and lumbar disc herniation; MMP9 defects cause metaphyseal anadysplasia type 2.
References in periodicals archive ?
The MMSE score of Group B after operation was significantly higher than that of Group A (p<0.05, Table-I).Next, we detected serum biomarkers for brain injury, such as NSE, S100[beta] and MMP9. The results showed that serum levels of these biomarkers in Group B at 0 h, 6 h and 12 hour after the operation were significantly lower compared to those of Group A (p<0.05, Table-II).
Based on this, our study aimed to analyze the potential interference of administration of TA and PRP in culture of healthy chondrocytes, extracted from healthy metacarpophalangeal joints of horses, in relation to the gene expression of MMP13 and MMP9, IL-6 and ACAN.
No similar discernable changes in blood pressure, glucose or MMP9 levels were observed in study participants.
Matrix components are regulated by matrix metalloproteinases (MMPs) such as MMP2, MMP9 (9).
(15.) Timms PM, Mannan N, Hitman GA, Noonan K, Mills PG, Syndercombe-Court D, et al Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders?
Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by downregulating MMP2 and MMP9. Cancer Biol Ther.
Interleukin 6 regulation of matrix metalloproteinase (MMp-2 and MMP9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non hodgkin's lymphomas.
(16-18) Degradation of the extracellular matrix mediated by matrix metalloproteinases (MMPs) enzymes, such as MMP2 and MMP9, is one the mechanisms that contributed to the invasive characteristics of malignant cells.
In one case, the MMP9:TIMP3 ratio was elevated more than 300 times while cytology was normal.
Previous study suggested that many genes and signalling pathway are involved in early pregnancy, and some genes are essential for maintaining pregnancy, and the miscarriage was triggered by the dysfunction of these genes, such as cadherin 2 (CDH2), which is a gene of cell adhesion molecules (CAMs) [5]; collagen type VI alpha 3 chain (COL6A3), thrombospondin 1 (THBS1), fibronectin 1, integrin beta 4 (ITGB4) [6], which are all PI3KAkt signaling pathway genes; matrix metallopeptidase 14 (MMP14), vascular cell adhesion molecule 1 (VCAM1) [7], matrix metallopeptidase 9 (MMP9), which are all tumor necrosis factor (TNF) signaling pathway genes; additionally, MAPK signaling pathway [8] and Hippo signaling pathway [9] are involved in maintaining pregnancy.
Moreover, epithelial differentiation dysfunctional marker, cytokeratin 19 and matrixmetallo proteinase 9 (MMP9) are also overexpressed.
Matrix metalloproteinases MMP1, MMP2, MMP9 and their tissue inhibitors TIMP1, TIMP2, TIMP3 in head and neck cancer: An immunohistochemical study.