MMP8


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Related to MMP8: collagenase, MMP9, MMP2, TIMP-1, PubMed, MMP-1

MMP8

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 8, which degrades fibrillar type I, II and III collagens. It is involved in breaking down extracellular the matrix in physiological processes—e.g., embryonic development, reproduction, tissue remodelling and wound healing. It differs from most MMP family members in that it is stored in secondary granules within neutrophils and activated by autolytic cleavage.

Molecular pathology
Defects in MMP8 have been linked to arthritis and metastasis.
References in periodicals archive ?
Mantyla, "Detection of gingival crevicular fluid MMP8 levels with different laboratory and chair-side methods," Oral Diseases, vol.
Haptoglobin-MMP1 stimulates hyperkeratosis and acanthosis, promoting skin carcinogenesis, a process enhanced by MMP8 absence in defective inflammatory responses, and inhibited MMP9 absence (a mechanism involved in prolonged contact dermatitis) [23, 109, 110].
During the study, researchers genetically engineered mice to lack the MMP8 enzyme.