MMP7


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MMP7

A gene on chromosome 11q21-q22 that encodes matrix metalloproteinase 7, which degrades proteoglycans, fibronectin, elastin and casein and activates procollagenase. It is involved in breaking down the extracellular matrix in physiological processes—e.g., embryonic development, reproduction, tissue remodelling and wound healing. It differs from most MMP family members as it lacks a conserved C-terminal protein domain.
 
Molecular pathology
Defects in MMP7 have been linked to arthritis and metastasis.
References in periodicals archive ?
(A) Lesion gene expression of Pgr, Esrl, Esr2, Ltf, Mmp9, Mmp7, Muc4, NR1I3, and Ccl2 from ovariectomized mice treated with vehicle (veh) (n =11 from 11 mice), Ethinylestradiol (EE) (n = 14 from 14 mice), BPA 30 (n = 11 from 9 mice), 300 (n = 12 from 9 mice), and 900ppm (n = 12 from 9 mice), or BPAF 30 (n =11 from 10 mice), 300 (n = 11 from 10 mice), and 900 ppm (n = 13 from 10 mice).
For estimating all the parameters, ELISA (Enzyme linked immunosorbent assay) was done with commercially available Accu Bind ELISA reagent kit for urinary free PSA (LOT EIA23KIA6H581) and Ray Biotech ELISA reagent kit for human MMP7 (Lot#: 1219140222), MMP13 (Lot#: 1219140175), TIMP1 (Lot#: 1219140191) and TIMP2 (Lot#: 1219140192).
Oue et al., "MicroRNA-148a is downregulated in gastric cancer, targets MMP7, and indicates tumor invasiveness and poor prognosis," Cancer Science, vol.
This leads to decreased MMP7 transcription and expression, with consequent reduced E-cadherin degradation.
Thus, HB-EGF is removed by MMP3 and MMP7 in tumor proliferation and angiogenesis, E-cadherin by MMP3 and MMP7, in tumor invasion, and TNF-[alpha] by MMP7, in tumor apoptosis [67].
[beta]-catenin also contributes to the activation of genes involved in the acquisition of migratory and invasive capabilities, such as Snail2/Slug, MMP7, vimentin and fibronectin (74, 75).
Konishi et al., "MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis," PLoS Medicine, vol.
Moreover, MMP-3 can stimulate other enzymes in the MMP group, such as MMP-1, MMP7, MMP-8, MMP-9, and MMP-13.
We assessed expression of estrogen receptor 1 (ESR1), progesterone receptor (PGR), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2, alias HER2), epoxide hydrolase 1 (EPHX1), baculoviral IAP repeat-containing 5 (BIRC5), matrix metal-lopeptidase 7 (MMP7), vascular endothelial growth factor A (VEGFA), topoisomerase (DNA) II alpha 170kDa (TOP2A), and ribosomal protein L37a (RPL37A) by quantitative 1-step reverse transcription PCR (RT-qPCR).
A consortium of researchers led by Baylor College of Medicine in Houston found that the allergen breathed in by asthmatics triggers the enzyme MMP7, which activates a cascade of events to prompt an allergic reaction.
This had already been reported by various authors [Perou, 1961; O'Connor et al., 1985; Urban et al., 2002], who have also demonstrated that the expression of some metalloproteinases (MMP2, MMP9 and MMP7) was significantly increased compared with the aorta controls, whereas no inflammatory cells were to be observed in the tissue samples.