MMP3


Also found in: Acronyms.

MMP3

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 3, which degrades fibronectin, laminin, collagens III, IV, IX and X, and cartilage proteoglycans. MMP3 is thought to be involved in wound repair, progression of atherosclerosis, and tumour initiation.
 
Molecular pathology
Defects in MMP3 cause susceptibility to coronary heart disease type 6.
References in periodicals archive ?
(2009) Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene.
Moreover, the Generalized Multifactor Dimensionality Reduction (GMDR, v0.9; http://www.ssg.uab.edu/gmdr/) [16, 17] analysis was used to calculate the interaction among five studied polymorphisms (-1607 1G/2G MMP1 (rs1799750), -735 C/T MMP2 (rs2285053), -1306 C/T MMP2 (rs243865), -1171 5A/6A MMP3 (rs35068180), and -1562C/T MMP9 (rs3918242)) in predicting of the occurrence of preeclampsia.
The following sequences were used for quantitative PCR (forward/reverse): ATP5O: 5'-AACGACTCCTTGGGTATTGCTTAA-3'/5'ATTGAAGGTCGCTATGCCACAG-3', ADIPOQ: 5'-TTTGGAGTGTTGGTAGGTGTCTGT-3'/5'GGGACATAGGTAAGAGGAAGTAGAGT-3', LIPE: 5'-GAAGACTCTGCAGGGATCCAATA-3'/5'TTTGGATGTAAGGTGATTGCTGTGG-3', Wingless-type family member 5A (WNT5A): 5'-CCAGTTCAAGACCGTGCAGAC-3'/5' CACACAAACTGGTCCACGATCTC-3', Fibroblast growth factor 5 (FGF5): 5'-CTTGAACAGCTGGAGGAATACATTTTA3'/5'TGGGACTTGGCATGGATAACTGTT-3', MMP1:5' -ACATGCGCACAAATCCCTTCTAC3'/5'CTTGGGGTATCCGTGTAGCA-3', MMP2: 5'-GGGACAAGAACCAGATCACATACAG-3'/5'CGAGCAAAGGCATCATCCACT-3', MMP3: 5'-CTGCTTTGTCCTTTGATGCTGTC3'/5' AAACGAGGTCCTTGCTAGTAACTTCA-3'.
As for biomarkers evaluating the risk for cardiovascular events in diabetic patients, MMP3, osteopontin and N-terminal prohormone of B-type natriuretic peptide (NT-proBNP), and their combined value score are currently proposed to be introduced in evaluating diabetic patients, but first there is a need for more clear evidence that their use offers a more accurate risk stratification than the traditional risk factors [14].
These studies are perhaps verified by cell culture analyses that have shown upregulation of ADEs such as NEP, ECE, ACE, ECE-2, IDE, and MMP2, MMP3, and MMP9 on exposure to A[beta] [42, 43, 45-47].
The expression of matrix metalloproteinase 2 (MMP2), MMP3, MMP13, a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), ADAMTS5, interleukin 6 (IL6), C-C motif ligand 2 (CCL2), CCL5, and C-X-C motif ligand 10 (CXCL10) in NP cells was analyzed to investigate the SASP of rat NP cells.
The most important genes clustering CTCs in the subgroups were cadherin 2 (CDH2), collagen type I alpha 2 chain (COL1A2), collagen type V alpha 2 chain (COL5A2), fibronectin 1 (FN1), microtubule associated protein 1B (MAP1B), matrix metallopeptidase 3 (MMP3), SRY-box 10 (S0X10), secreted phosphoprotein 1 (SPP1), zinc finger E-box binding homeobox 1 (ZEB1), and zinc finger E-box binding homeobox 2 (ZEB2; Fig.
The authors reported that Men-SCs were able to produce matrix metalloproteinase-3 (MMP3), MMP10, granulocyte macrophage colony-stimulating factor (GM-CSF), angiopoietin-2, and platelet-derived growth factor (PDGF)-BB in quantities 10 to 10,000 times higher than those in umbilical cord blood cells.
Due to structural and substrate specificity, MMPs are currently divided into seven classes: collagenases (MMP1, MMP8, MMP13, and MMP18), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP10), stromelysin like (MMP11 and MMP12), matrilysins (MMP7 and MMP26), membrane type (MMP14, MMP15, MMP16, MMP17, MMP24, and MMP25), and others (MMP19, MMP20, MMP21, MMP22, MMP23, MMP27, and MMP28) [18, 27, 28].
En relacion con el grupo de las gelatinasas (MMP-2 y MMP-9), colagenasas (MMP-13) y estromelinas (MMP3), autores como Iamaroon y colaboradores (36), Morris y colaboradores (23,24), Mansell y colaboradores (25), Blavier y colaboradores (37), Brown y colaboradores (38), de Oliveira y colaboradores (39), Gkantidis y colaboradores (40) e Hirata y colaboradores (41) han demostrado, al usar diferentes tecnicas de laboratorio, su implicacion en la palatogenesis en el raton.