MMP3


Also found in: Acronyms.

MMP3

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 3, which degrades fibronectin, laminin, collagens III, IV, IX and X, and cartilage proteoglycans. MMP3 is thought to be involved in wound repair, progression of atherosclerosis, and tumour initiation.
 
Molecular pathology
Defects in MMP3 cause susceptibility to coronary heart disease type 6.
References in periodicals archive ?
MMP3, MMP7, MMP9, and MMP19 stimulate tumor growth by releasing IGF (insulin-like growth factor) [20].
MMP3 is expressed in tumoral stroma of invasive breast cancer along with MT1-MMP, MMP1, MMP2, and MMP11 [105].
MMP gene polymorphisms as contributors for clef lip/palate : association with MMP3 but not MMP1.
For instance, it's not clear how MMP3 activates Rac1b, he says.
ELISA: Levels of MMP1 and MMP3 in culture supernatant were measured using enzyme immunoassay (Quantikine, R&D systems, Minneapolis, USA).
Our results in the present study suggest that MMP3 levels in serum samples are useful measure of the activity of synovitis in RA.
The study also evaluated whether plasma MMP3 values could have served as a surrogate marker in the original doxycycline trial.
Expression and regulation of MMP1, MMP3, and MMP9 in the chicken ovary in response to gonadotropins, sex hormones, and TGFB1.
Recently, our group demonstrated a correlation between the MMP3 polymorphism and breast cancer (16).
Genetic analysis of MMP3, MMP9, and PAI-1 in Finnish patients with abdominal aortic or intracranial aneurysms.
MMP3 (stromelysin-1; also known as STR1, STMY1, MIM 185250) has recently emerged as an interesting candidate for a mammary tumor accelerator that may also influence tumor initiation and modify breast cancer risk (2).
In addition to degrading numerous extracellular-matrix components, MMP3 can activate gelatinase B and the collagenases and release several cell surface molecules, including E-cadherin, a known contributor to cancer development (6).