MMP26

MMP26

A gene on chromosome 11p15 that encodes membrane-type matrix metalloproteinase 26, which activates progelatinase B and may hydrolyse collagen type IV, fibronectin, fibrinogen, beta-casein, type-I gelatin and alpha-1 proteinase inhibitor. MMP26 is expressed specifically in the uterus and placenta, and widely expressed in various malignancies.
References in periodicals archive ?
Metalloproteinases belong to a large family of zinc-dependent endopeptidases that include collagenases (e.g., MMP1, MMP8, and MMP13), gelatinases (MMP2, MMP9), stromelysins (MMP3, MMP10), matrilysins (MMP7, MMP26), and transmembrane metalloproteinases types I and II.
Matrilysins (MMP-7 and MMP26) are the smallest members of the family that lack the hemopexin-like domain.
Due to structural and substrate specificity, MMPs are currently divided into seven classes: collagenases (MMP1, MMP8, MMP13, and MMP18), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP10), stromelysin like (MMP11 and MMP12), matrilysins (MMP7 and MMP26), membrane type (MMP14, MMP15, MMP16, MMP17, MMP24, and MMP25), and others (MMP19, MMP20, MMP21, MMP22, MMP23, MMP27, and MMP28) [18, 27, 28].