MMP20

MMP20

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 20, which degrades amelogenin, the major protein of the enamel matrix, and two macromolecules of the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein. MMP20 may play a central role in tooth enamel formation. It is also the retired HUGO symbol for what is now designated MMP25, see there.

Molecular pathology
Defects in MMP20 cause amelogenesis imperfecta type 2A2.
References in periodicals archive ?
In genetic factor tooth agenesis can be either non-syndromic or syndromic and the genes responsible for hypodontia are MSX1, PAX9, WNT10A, AXIN2, TGFA, IRF6, MMP1, MMP20 and FGF311-13.
Estudio analitico de corte transversal, en el que se estudiaron caracteristicas epidemiologicas, bioquimicas y se evaluo la expresion genica de TGF-P1, COL1A2 y MMP20 en tejido hepatico, y su posible asociacion con la presencia de NAFLD.
It arises from mutations that occur in one or more than one of four genes that are known to play a role in enamel formation, namely, amelogenin (AMELX), enamelin, enamelysin (MMP20), and kallikrein (KLK4).
It has been reported that a concentration of 10 [micro]M of F- produces a decrease in the expression of MMP20, (46), 47 concentrations of 10 to 20 [micro]M of F- produce an increase in apoptosis, and concentrations above 1 mM produce alterations in cell proliferation.
Besides MMP-2 and MMP-3, putative NLSs in the sequences of MMP-1, MMP-8, MMP-10, MMP-13, MMP-19, MMP20, and MMP-23 and MT1-MMP, MT3-MMP, MT4-MMP, and MT5-MMP were also detected [31], which suggests that nuclear entry may be a feature of many MMPs.
Due to structural and substrate specificity, MMPs are currently divided into seven classes: collagenases (MMP1, MMP8, MMP13, and MMP18), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP10), stromelysin like (MMP11 and MMP12), matrilysins (MMP7 and MMP26), membrane type (MMP14, MMP15, MMP16, MMP17, MMP24, and MMP25), and others (MMP19, MMP20, MMP21, MMP22, MMP23, MMP27, and MMP28) [18, 27, 28].
MMP20 mutation in autosomal recessive pigmented hypomaturation amelogenesis imperfecta.
(16) Several genes have been implicated in the development of amelogenesis imperfecta, including AMELX, ENAM, DLX3, FAM83H, MMP20, KLK4, and WDR72.
Genetic variation in MMP20 contributes to higher caries experience.
Golden Systems Middle East (GSME), a leading distributor of IT products in the Middle East, has announced the launch of the new Kingmax mSATA solid state drive (SSD) MMP20 in the Middle East region.
Summary: Golden Systems Middle East (GSME), a distributor of IT products in the Middle East, recently announced the launch of the new Kingmax mSATA SSD MMP20 in the Middle East region.