MMP2


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Related to MMP2: MMP9, TIMP1, TIMP3

MMP2

A gene on chromosome 16q13-q21 that encodes matrix metalloproteinase 2, a ubiquitinous metalloproteinase that degrades type-IV collagen and is involved in remodelling vasculature, endometrial menstrual breakdown, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture.

Molecular pathology
MMP2 mutations cause Torg-Winchester syndrome and nodulosis-arthropathy-osteolysis syndrome.
References in periodicals archive ?
It has been observed that cellular degeneration is minimal in the treatment of Ganoderma lucidum, VEGF protein expression in vascular endothelial cells and integrity is preserved because MMP2 expression is positive in the basement membrane.
The current study was planned to evaluate the efficacy of CLA supplementation on MMP9 and MMP2 and some inflammatory factors in young healthy males during exhaustive exercise.
MMP2 promotes the migration of breast malignant carcinomatous cells by cleaving and regulating laminin-5 (Ln-5), as a specific ECM glycoprotein [86].
Fernandis AZ et al reported that stimulation of MDA-MB-231 breast carcinoma cells by SDF-1 leads to release of MMP2 and MMP9 and to increase cellular motility and migration (17).
Interestingly, the lower doses of andrographolide appeared to significantly suppress cartilage degrading parameters in cartilage explant model compared to those of andrographolide which was required for powerful downregulation of MMP2 expression in primary chondrocyte culture.
Association between MMP2, MMP9 expression in normal prostatic tissue and with the different lesions studied was achieved by Spearman test.
MC (Mesangial cells) from diabetic non-obese diabetic (NOD) mice secrete increased amounts of IGF-1 and this probably contributes to the increased ECM accumulation, largely through an IGF-1 mediated reduction in MMP2 activity.
29) Other authors have also found a high expression of MMP2 in OM.
The metallobodies were selective for just two members of the MMP family -- MMP2 and 9 -- and they bound tightly to both the mouse versions of these enzymes and the human ones.
The expression of human corneal MMP2, MMP-9, proMMP-13 and TIMP-1 in bullous keratopathy and keratoconus.
Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2.
Overexpression of FoxM1 potentiated cell proliferation, cell transformation, and migration/invasion of CRC cells via up-regulation of FoxM1 target genes MMP2 and MMP9 and protected these cells from thiostrepton-mediated antiproliferative effects.