MMP2


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Related to MMP2: MMP9, TIMP1, TIMP3

MMP2

A gene on chromosome 16q13-q21 that encodes matrix metalloproteinase 2, a ubiquitinous metalloproteinase that degrades type-IV collagen and is involved in remodelling vasculature, endometrial menstrual breakdown, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture.

Molecular pathology
MMP2 mutations cause Torg-Winchester syndrome and nodulosis-arthropathy-osteolysis syndrome.
References in periodicals archive ?
To our knowledge, there are no standard normative data for urine levels of MMP2, MMP9, TIMP1, TIMP2, TGF-p1 in children by age group.
Our findings showed that the administration of 450g probiotic yoghurt to the supplement group for two weeks modulated the serum levels of TNF-[alpha], MMP2, MMP9, MDA, and lipid peroxidation consistent with the previous studies.8,25,26 Several studies indicated that some strains of probiotics positively prevent and correct oxidative stress in humans through their direct antioxidative activity and modulate the immune system.3,27,28 Probiotic yoghurt administration improved GPX and TAC at the end of supplementation and exhaustive exercise.
Changes in MMP2 levels have been reported to be altered in the placental tissue of gestational hypertension.
Moreover, the Generalized Multifactor Dimensionality Reduction (GMDR, v0.9; http://www.ssg.uab.edu/gmdr/) [16, 17] analysis was used to calculate the interaction among five studied polymorphisms (-1607 1G/2G MMP1 (rs1799750), -735 C/T MMP2 (rs2285053), -1306 C/T MMP2 (rs243865), -1171 5A/6A MMP3 (rs35068180), and -1562C/T MMP9 (rs3918242)) in predicting of the occurrence of preeclampsia.
Schaffler, "Multicentric osteolysis with nodulosis, arthritis, and cardiac defect syndrome: loss of MMP2 leads to increased apoptosis with alteration of apoptotic regulators and caspases and embryonic lethality," Advances in Genomics and Genetics, vol.
Furthermore, a difference in the gene for matrix metalloproteinase (MMP2), an enzyme found in teeth, was linked to increased filling failure.
Furthermore, people with a difference in the gene for matrix metalloproteinase (MMP2) - an enzyme found in teeth - were at increased risk of filling failure.
Winchester syndrome is caused by an alteration in a gene called MMP2. Symptomatic treatment can be given with anti-inflammatory drugs and skeletal muscle relaxants.
Matrix metalloproteinase-2 (MMP2), one of the most ubiquitous members of the matrix metalloproteinase family, cleaves collagen type IV of the extracellular matrix maintaining equilibrium between matrix synthesis and degradation, thus providing a critical role in the cell integrity and cell survival (Malemud, 2006).
observed that cantharidin could inhibit pancreatic cancer cells to invade and downregulate the expression of matrix metalloproteinase 2 (MMP2).
observed that pretreatment with ursolic acid inhibited UVA-induced oxidative stress and activation and expression of MMP2 in HaCaT human keratinocytes.