MMP19

MMP19

A gene on chromosome 12q14 that encodes matrix metalloproteinase 19, an endopeptidase that degrades components of the extracellular matrix, including collagen IV, laminin, nidogen, nascin-C isoform, fibronectin and type I gelatin, playing a role in development, haemostasis and pathological conditions (e.g., arthritic disease). It is widely expressed except in the brain and peripheral white cells.
References in periodicals archive ?
MMP3, MMP7, MMP9, and MMP19 stimulate tumor growth by releasing IGF (insulin-like growth factor) [20].
VEGF (vascular endothelial growth factor) stimulates tumor angiogenesis, being released by MMP3, MMP7, MMP9, and MMP19 [20].
2-4) Secreted-type MMPs can be classified into 6 subgroups according to their substrate specificity and structural differences (2): (1) collagenases, including tissue collagenase (MMP1), neutrophil collagenase (MMP8), and collagenase 3 (MMP13); (2) gelatinases, such as gelatinase A (MMP2) and gelatinase B (MMP9); (3) stromelysins, including stromelysin 1 (MMP3) and stromelysin 2 (MMP-10); (4) matrilysins, such as matrilysin 1 (MMP7) and matrilysin 2 (MMP26); (5) furin-activated MMPs, including stromelysin 3 (MMP-13) and epilysin (MMP 28); and (6) other MMPs such as metalloelastase (MMP12), MMP19, enamelysin (MMP-20), MMP21, and MMP-27.