MMP17

MMP17

A gene on chromosome 12q24.3 that encodes membrane-type matrix metalloproteinase 17. Unlike other matrix metalloproteinaes, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP17 is membrane bound as a GPI-anchored protein. It activates MMP2 by cleavage; it does not hydrolyse collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin or alpha1-antitrypsin.
References in periodicals archive ?
Due to structural and substrate specificity, MMPs are currently divided into seven classes: collagenases (MMP1, MMP8, MMP13, and MMP18), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP10), stromelysin like (MMP11 and MMP12), matrilysins (MMP7 and MMP26), membrane type (MMP14, MMP15, MMP16, MMP17, MMP24, and MMP25), and others (MMP19, MMP20, MMP21, MMP22, MMP23, MMP27, and MMP28) [18, 27, 28].