MMP16

MMP16

A gene on chromosome 8q21.3 that encodes matrix metalloproteinase 16, an endopeptidase that degrades components of the extracellular matrix, including collagen III and fibronectin, and activates progelatinase A. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP16 is a transmembrane protein that is activated from its precursor by furin endopeptidase cleavage. It is expressed in the heart, brain, placenta, ovaries and small intestine.

Molecular pathology
Interaction of MMP16 and CSPG4 may trigger degradation and invasion of type-I collagen by melanomas.
References in periodicals archive ?
MMP2 (collagenase IV) and MMP16 (activates MMP2) expression was significantly upregulated at all time points, suggesting a detrimental role in wound healing processes [93].
miR-146b-5p inhibits glioma migration and invasion by targeting MMP16.
Due to structural and substrate specificity, MMPs are currently divided into seven classes: collagenases (MMP1, MMP8, MMP13, and MMP18), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP10), stromelysin like (MMP11 and MMP12), matrilysins (MMP7 and MMP26), membrane type (MMP14, MMP15, MMP16, MMP17, MMP24, and MMP25), and others (MMP19, MMP20, MMP21, MMP22, MMP23, MMP27, and MMP28) [18, 27, 28].
6] ACTB molecules included MMP16, TPBG, LGALS9, CDC20, RAG1, and IFNG.
Genes with several nondetectable observations--CDC20, LGALS9, MMP16, and TPBG--were more skewed.
MMP16 concentrations were below the limit of detection in all samples; because MMP16 is not expressed in peripheral blood cells, this measurement was included to test the QC of the methods used (19, 20).