MMP14

MMP14

A gene on chromosome 14q11-q12 that encodes matrix metalloproteinase 14, which specifically activates progelatinase A. It may be involved in actin cytoskeleton reorganisation by cleaving PTK7. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP14 is a transmembrane protein that is activated from its precursor by furin endopeptidase cleavage.

Molecular pathology
MMP14 may trigger invasion by tumour cells by activating progelatinase A on the surface of tumour cells.
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References in periodicals archive ?
MiR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14. PLoS One 2014; 9: e108435
Swingler et al., "MMP14 and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction," Biochimica et Biophysica Acta, vol.
Similarly, miR181a-5p and miR-2127 are potential tumour suppressor miRNAs as miR-181a-5p inhibits cell proliferation via MMP14, which is a matrix metalloproteinase enzyme.
MMP2 (rs243865, rs2285053, rs243847, (2012) (20) rs2287074, rs9923304, rs11639960) MMP3 (rs639752, rs650108, rs679620, rs522616) MMP9 (rs3918253, rs17576, rs17577) MMP13 (rs2252070) MMP14 (rs1042704) TIMP2 (rs9894526) Salazar-Pelaez et al.
In the present study, the expression of MMPs was detected by real-time PCR; we show that the mRNA levels of MMP2 and MMP14 were upregulated in GDM group ( n = 18) compared with those in normal pregnant women (CON) group ( n = 16) [Figure 1]a.
Two DEGs of LILRA4 (a) and CDH2 (b) at 18 d, MMP14 (c) and VCAM1 (d) at 21 d, LOC100139209 (e) and LILRA4 (f) at 33 d, EEF1A1 (g) and PRSS2 (h) at 39 d, and BoLA-DQA (i) and BoLA-DQB (j) at 51 d post-artificial insemination (AI) was further confirmed by real-time PCR.
Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy.
In various studies, it was emphasized that the ECM network containing hyaluronan, MMP14 and lysyl oxidase may have therapeutic effect (44).
A correlation between metalloproteinase MMP14 expression and overall survival was reported in 1 study of 9 patients with MPM treated by standard thoracotomy for therapeutic purposes, compared to 4 normal pleural samples.
Evidence for the involvement of MMP14 in MMP2 processing and recruitment in exosomes of corneal fibroblasts.