Particularly, MT-MMP1 (MMP14
) mediated activation of proMMP2 has been studied extensively, and it requires the assistance of TIMP2.
MiR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14
. PLoS One 2014; 9: e108435
Swingler et al., "MMP14
and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction," Biochimica et Biophysica Acta, vol.
Similarly, miR181a-5p and miR-2127 are potential tumour suppressor miRNAs as miR-181a-5p inhibits cell proliferation via MMP14
, which is a matrix metalloproteinase enzyme.
NEDD9 depletion leads to MMP14
inactivation by TIMP2 and prevents invasion and metastasis.
MMP2 (rs243865, rs2285053, rs243847, (2012) (20) rs2287074, rs9923304, rs11639960) MMP3 (rs639752, rs650108, rs679620, rs522616) MMP9 (rs3918253, rs17576, rs17577) MMP13 (rs2252070) MMP14
(rs1042704) TIMP2 (rs9894526) Salazar-Pelaez et al.
In the present study, the expression of MMPs was detected by real-time PCR; we show that the mRNA levels of MMP2 and MMP14
were upregulated in GDM group ( n = 18) compared with those in normal pregnant women (CON) group ( n = 16) [Figure 1]a.
Two DEGs of LILRA4 (a) and CDH2 (b) at 18 d, MMP14
(c) and VCAM1 (d) at 21 d, LOC100139209 (e) and LILRA4 (f) at 33 d, EEF1A1 (g) and PRSS2 (h) at 39 d, and BoLA-DQA (i) and BoLA-DQB (j) at 51 d post-artificial insemination (AI) was further confirmed by real-time PCR.
Blockade of MMP14
activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy.
In various studies, it was emphasized that the ECM network containing hyaluronan, MMP14
and lysyl oxidase may have therapeutic effect (44).
A correlation between metalloproteinase MMP14
expression and overall survival was reported in 1 study of 9 patients with MPM treated by standard thoracotomy for therapeutic purposes, compared to 4 normal pleural samples.
Evidence for the involvement of MMP14
in MMP2 processing and recruitment in exosomes of corneal fibroblasts.