MMP13

MMP13

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 13, which cleaves collagens I in the extracellular matrix. MMP13 may play a role in turnover of articular cartilage.

Molecular pathology
Defects in MMP13 cause spondyloepimetaphyseal dysplasia Missouri type and metaphyseal anadysplasia type 1. MMP13 may play a role in the pathogenesis of osteoarthritis.
References in periodicals archive ?
9) Bonaldi and Morgia et al have also cited increased serum level of MMP13 in prostatic carcinoma patients in different studies.
Aumento de IL-11 y mieloperoxidasa Nanotubos de carbono Nanotubos de carbono Aumento de IL-4, IL-5, 33,34,36-38 IL-i 3, IL-33, IFN- [gamma], IL-17A, IL-23, TGF-[beta], PDGF-AA, CCL3, CCLii, eotaxina, IgGi; afluencia de macrofagos, eosinofilos y neutrofilos; produccion de colageno, moco y MMP13 Disminucion de la 39-42 respuesta de linfocitos T.
Global Markets Direct's, 'Collagenase 3 (Matrix Metalloproteinase-13 or MMP13 or EC 3.
Normally Hes1 acts as a transcriptional repressor but under the influence of calcium/calmodulin-dependent protein kinase 2 (CaMK2) it becomes a transcriptional activator, thus upregulating MMP13 expression [34].
Antibodies used in this study are the following: p-CREB (SC-101663), tyrosinase (SC-15341), MITF (SC-11002), MMP1 (SC-12348), MMP9 (SC-6840), MMP12 (sC-30072) MMP13 (SC-12363), type 1 procollagen (SC-25973), type 3 procollagen (SC-8779), p-p65 (S536) (SC-33020), iNOS (SC-8310), [beta]-actin (SC-47778), and TFIIB (SC-225).
Due to structural and substrate specificity, MMPs are currently divided into seven classes: collagenases (MMP1, MMP8, MMP13, and MMP18), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP10), stromelysin like (MMP11 and MMP12), matrilysins (MMP7 and MMP26), membrane type (MMP14, MMP15, MMP16, MMP17, MMP24, and MMP25), and others (MMP19, MMP20, MMP21, MMP22, MMP23, MMP27, and MMP28) [18, 27, 28].
Algunos genes involucrados en la morfogenesis craneofacial son: senales polarizantes (SHH,BP2,BMP4,BMP7; Smad 2-4), factores de crecimiento receptores (EGF,EGFR,TGF- alfa, TGFbeta 1-3,FGF1, FGF2, FGF8), factores de transcripcion (AP2-alfa, DLX 1-6, Gli 2 -3, PITX1, PITX2, PRX1, HOXA2, LRF6, LHX8,PAX9,MSX1,TBX1,TBX22), moleculas de adhesion celular (PBRL1, Conexin 43, E-Cadherina), matriz extracelular (COL2A1, COL11A1, COL11A2, MMP2, MMP3, MMP9, MMP13, MP1-3, fibronectina).
It appears to work by inhibiting IL-1[beta], IL-6, IL-8, NF-[kappa]B, TNF[alpha], MMP-3, MMP-9, MMP13, caspase-3, and COX-2 and enhancing chondrogenesis.
MMP13 is viewed as a potential tumor marker for breast cancer diagnosis, and its expression is correlated with metastasis formation (39).
Washington, July 7 ( ANI ): Researchers used human tissue samples to discover that those with osteoarthritis have a signature epigenetic change, DNA methylation, which is responsible for switching on and off a gene that produces a destructive enzyme called MMP13.
We and others have shown that blocking (EP4 receptor) or induction of PGE2 receptor, EP2 can block MMP13 expression in OA chondrocytes.