Matrix metalloproteinases (MMP) 1 and MMP10
but not MMP12 are potential oral cancer markers.
It has been reported that ERCs can differentiate into alveolar epithelial cells and secretion of MMP3 and MMP10
at 10100,000-fold higher levels than mesenchymal stem cell lines .
Metalloproteinases belong to a large family of zinc-dependent endopeptidases that include collagenases (e.g., MMP1, MMP8, and MMP13), gelatinases (MMP2, MMP9), stromelysins (MMP3, MMP10
), matrilysins (MMP7, MMP26), and transmembrane metalloproteinases types I and II.
Despite the limited size of the two groups, an additional analysis to find a putative effect of the treatment on the candidate genes (IL1RN and C4BP4 for UC and CCL11 and MMP10
for CD) has been performed separately both on UC and CD groups.
Activation of the PKC pathway stimulates ovarian cancer cell proliferation, migration, and expression of MMP7 and MMP10
. Biol Reprod 2013; 89: 73.
pylori are associated with cell cycle progression and proliferation (p14, p16, p21, p27, RAB40C, COX 2, FOS, ERBB2, FGFR2, ABL1, ECOP, JAK2, MYC, MET, SIRT1, PDCD4, TRAF6, GMNN, and CCNE2) [213, 223-242], apoptosis (RECK, SMAD4, TRAIL, MCL1, BIM, XIAP, and PDK1) [243-250], and invasion and metastasis (pTEN, WNT 5a, EDNRA, ROR2, EPB41L3, MMP1, MMP10
, HMGA2, ROBO1, TGF-[beta], EZH2, casein kinase 2, and ZEB) [251-262].
In contrast, the incubation with IFN-[gamma]/LPS stimulated the production of a wide assortment of MMPs (MMP1, MMP2, MMP7, MMP8, MMP10
, and MMP13), but did not affect MMP12 secretion (Figure 5(b)).
Chang et al., "Matrix metalloproteinases (MMP) 1 and MMP10
but not MMP12 are potential oral cancer markers," Biomarkers, vol.
The authors reported that Men-SCs were able to produce matrix metalloproteinase-3 (MMP3), MMP10
, granulocyte macrophage colony-stimulating factor (GM-CSF), angiopoietin-2, and platelet-derived growth factor (PDGF)-BB in quantities 10 to 10,000 times higher than those in umbilical cord blood cells.
The N-terminal part of the fusion protein is critical for transforming activity, and the fusion protein activates epidermal growth factor receptor signaling in an autocrine manner and activates transcription of cAMP/cAMP response element-binding protein target genes including phosphoenolpyruvate carboxykinase 1; amphiregulin; MMP10
; interleukin 6; nuclear receptor subfamily 4, group A, member 2; and nuclear receptor subfamily 4, group A, member 3.
Due to structural and substrate specificity, MMPs are currently divided into seven classes: collagenases (MMP1, MMP8, MMP13, and MMP18), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP10
), stromelysin like (MMP11 and MMP12), matrilysins (MMP7 and MMP26), membrane type (MMP14, MMP15, MMP16, MMP17, MMP24, and MMP25), and others (MMP19, MMP20, MMP21, MMP22, MMP23, MMP27, and MMP28) [18, 27, 28].
The incomplete degradation of 3D/FN and 3D/LN structures may reflect the low or lack of expression of MMPs specific for these ECM proteins, namely, MMP7, MMP10
, MMP11, MMP14, and MMP15 for LN and MMP7, MMP10
, MMP11, MMP12, MMP14, and MMP15 for FN.