MMP2

(redirected from MMP-II)

MMP2

A gene on chromosome 16q13-q21 that encodes matrix metalloproteinase 2, a ubiquitinous metalloproteinase that degrades type-IV collagen and is involved in remodelling vasculature, endometrial menstrual breakdown, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture.

Molecular pathology
MMP2 mutations cause Torg-Winchester syndrome and nodulosis-arthropathy-osteolysis syndrome.
References in periodicals archive ?
However, MMP-II too shows low detection rate in PB cases.
11) Here, we evaluated the use of MMP-II as a tool for sero-diagnosis of leprosy in Indonesia, which is an endemic countries with foci of high leprosy rates.
The MMP-II protein used as antigen was purified as a fusion protein in E.
None of the tuberculosis patients and two of the typhoid patients had antibodies against MMP-II.
A comparison of antibody levels were in patients with PB leprosy and healthy controls showed that a MMP-II antibody levels were significantly higher p < 0.
This report indicates that MMP-II could contribute to the sero-detection of MB as well as PB leprosy patients in leprosy endemic countries, where other environmental mycobacterial infections may be more prevalent, such as in Indonesia.
DIFFERENTIAL EFFECTS OF HYDROGEN PEROXIDE ON MMP-I, MMP-II, AND TGF-[beta] MRNA LEVELS IN RENAL CANCER CELLS
MMP-II and TGF-[beta] were significantly stimulated at higher concentrations of hydrogen peroxide.
leprae infection' Linda Oskam, 'New and improved opportunities for serological KIT, The Netherlands KIT, testing in leprosy' John Spencer, 'Use of Western blot, ELISA and protein microarrays to define disease-state-specific CSU, USA antigenic profiles in leprosy patients' Sang-Nae Cho, 'Enzyme immunoassays for PGL-I antigen and antibodies' YUMC, Korea Yumi Maeda, 'Recent findings of the use of the MMP-II protein as a potential diagnostic for LCR, Tokyo, Japan leprosy detection using serology' Juan Periche 'Difficulties in leprosy diagnosis' Fernandez, IDCP-Dr.
Yumi Maeda: 'Recent findings of the use of the MMP-II protein as a potential diagnostic for leprosy detection using serology'