MMP9

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MMP9

A gene on chromosome 20q12-q13 that encodes matrix metalloproteinase 9, which degrades collagens IV and V, gelatins I and V, and fibronectin. It is thought to play a key role in local proteolysis of the extracellular matrix and in leukocyte migration, and may play a role in osteoclastic resorption of bone.

Molecular pathology
Defects in MMP9 increase susceptibility to intervertebral disc disease and lumbar disc herniation; MMP9 defects cause metaphyseal anadysplasia type 2.
References in periodicals archive ?
MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas.
Gelatin zymography assay was performed to evaluate the activity of MMP-2 and MMP-9 as previously described (12).
The authors concluded that serum MMPs can be used as adjuvant biomarkers (combined with PSA) for the diagnosis (MMP-13) and prognosis (MMP-2 and MMP-9) of PCa.
The aim of this study to evaluate mutual relation between IL-6, CRP and MMP-9 serum levels in patients with CRC and their association with staging and clinical-pathological features of colorectal cancer.
MMP-9 levels were measured using an enzyme-linked immunosorbent assay (ELISA, Abcam[R], UK).
Lin et al., "IL-1[beta] promotes corneal epithelial cell migration by increasing MMP-9 expression through NF-kB- and AP-1-dependent pathways," PLoS One, vol.
The association of MMP-9 and TIMP-1 with severity and outcome of sepsis has already been recognised [7-15].
VEGF, MMP-2, MMP-9, and TIMP-1 protein levels were measured by western blot analysis.
In the present study, we clarified the inhibitory mechanisms of haloperidol on TNF-[alpha]-induced MMP-9 expression in human monocytic cells.
Our present study aimed to assess circulating pentraxin-3, galectin-3, MMP-9 and TIMP-1 concentrations in different stages of CKD, in both dialysis and non-dialysis patients, as well as in a control group.
The functions of the matrix are regulated, in part, by enzymes that break down matrix proteins; one of these enzymes is matrix metalloproteinase-9 (MMP-9).