MMP9

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MMP9

A gene on chromosome 20q12-q13 that encodes matrix metalloproteinase 9, which degrades collagens IV and V, gelatins I and V, and fibronectin. It is thought to play a key role in local proteolysis of the extracellular matrix and in leukocyte migration, and may play a role in osteoclastic resorption of bone.

Molecular pathology
Defects in MMP9 increase susceptibility to intervertebral disc disease and lumbar disc herniation; MMP9 defects cause metaphyseal anadysplasia type 2.

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metaphyseal anadysplasia

References in periodicals archive ?

MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas.

Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma

Gelatin zymography assay was performed to evaluate the activity of MMP-2 and MMP-9 as previously described (12).

Glycoprotein nonmetastatic melanoma protein B accelerates tumorigenesis of cervical cancer in vitro by regulating the Wnt/[beta]-catenin pathway

In male reproductive system, MMP-2 and MMP-9 are detected in seminal plasma.

Activity of Matrix Metalloproteinase 2 and 9 in Follicular Fluid and Seminal Plasma and Its Relation to Embryo Quality and Fertilization Rate

The authors concluded that serum MMPs can be used as adjuvant biomarkers (combined with PSA) for the diagnosis (MMP-13) and prognosis (MMP-2 and MMP-9) of PCa.

Diagnosis and Prognosis of Prostate Cancer from Circulating Matrix Metalloproteinases and Inhibitors

The aim of this study to evaluate mutual relation between IL-6, CRP and MMP-9 serum levels in patients with CRC and their association with staging and clinical-pathological features of colorectal cancer.

The Association of Simultaneous Increase in Interleukin-6, C Reactive Protein, and Matrix Metalloproteinase-9 Serum Levels with Increasing Stages of Colorectal Cancer

MMP-9 levels were measured using an enzyme-linked immunosorbent assay (ELISA, Abcam[R], UK).

Wound Fluid Matrix Metalloproteinase-9 as a Potential Predictive Marker for the Poor Healing Outcome in Diabetic Foot Ulcers

Lin et al., "IL-1[beta] promotes corneal epithelial cell migration by increasing MMP-9 expression through NF-kB- and AP-1-dependent pathways," PLoS One, vol.

IL-1[beta]-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway

The association of MMP-9 and TIMP-1 with severity and outcome of sepsis has already been recognised [7-15].

Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery

VEGF, MMP-2, MMP-9, and TIMP-1 protein levels were measured by western blot analysis.

Effect of Collagen Cross-Linking on Alkali Burn-Induced Corneal Neovascularization in Rabbits

In the present study, we clarified the inhibitory mechanisms of haloperidol on TNF-[alpha]-induced MMP-9 expression in human monocytic cells.

Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-[kappa]B Activation in Stimulated Human Monocytic Cells

Our present study aimed to assess circulating pentraxin-3, galectin-3, MMP-9 and TIMP-1 concentrations in different stages of CKD, in both dialysis and non-dialysis patients, as well as in a control group.

ASSOCIATION OF PENTRAXIN-3, GALECTIN-3 AND MATRIX METALLOPROTEINASE-9/TIMP-l WITH CARDIOVASCULAR RISK IN RENAL DISEASE PATIENTS