MMP9

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MMP9

A gene on chromosome 20q12-q13 that encodes matrix metalloproteinase 9, which degrades collagens IV and V, gelatins I and V, and fibronectin. It is thought to play a key role in local proteolysis of the extracellular matrix and in leukocyte migration, and may play a role in osteoclastic resorption of bone.

Molecular pathology
Defects in MMP9 increase susceptibility to intervertebral disc disease and lumbar disc herniation; MMP9 defects cause metaphyseal anadysplasia type 2.
References in periodicals archive ?
MMP-9 is a key enzyme in degrading type IV collagen, which is a major component of the basement membrane.
To find an explanation of the differences in MMP-9 concentrations among citrate plasma, serum, and serum with clot accelerators (Sca), we analyzed the effects of silicate on MMP in whole blood (WB), plasma, serum, and buffy coat (BC), as well as in culture media of U-937 myelomonocytic leukemia cells (SF U937).
These findings suggest that MMP-2 and MMP-9 are closely involved in inflammation and fibrosis.
Considering these findings, in this study we, aimed to investigate serum temporal concentrations of active MMP2 and active MMP-9 in a cohort of RRMS patients during 21 months of Natalizumab therapy.
Interestingly, in human alcoholics, the MMP-9 gene polymorphism that leads to a higher MMP-9 production correlates with greater motivation to drink alcohol, said Dr.
The pro-domains structure of MMP-1, MMP-2, MMP-3 and MMP-9 has been well determined.
Both MMP-2 and MMP-9 were shown to locate in the Golgi and trans-Golgi network both in nonreactive and in reactive astrocytes [28].
Notably, growing experimental evidence suggests the involvement of MMP-9 in the pathogenesis of MS, where its circulating levels in serum and cerebrospinal fluid (CSF) were found to be upregulated in MS patients compared with noninflammatory neurological disorders (NIND) and healthy controls [9-13].
sup][8],[9],[10] In a previous study, we confirmed that MMP-9 plays an important role in the formation of CAC in a mouse model of KD.
Plasma and urinary MMP-9, insulin assessed by ELISA, and the 2 h post-prandial venous plasma glucose (PPBS) estimation was also done.
In this study, we aimed to investigate whether clinical measures of disease activity and function in AS and IBD are associated with MMP-3, MMP-9 and TIMP-1, and if MMPs can be more useful than CRP and ESR in predicting disease activity in AS.