MMP8

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MMP8

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 8, which degrades fibrillar type I, II and III collagens. It is involved in breaking down extracellular the matrix in physiological processes—e.g., embryonic development, reproduction, tissue remodelling and wound healing. It differs from most MMP family members in that it is stored in secondary granules within neutrophils and activated by autolytic cleavage.

Molecular pathology
Defects in MMP8 have been linked to arthritis and metastasis.
References in periodicals archive ?
The first one includes so-called collagenases, such as MMP-1 (interstitial, fibroblast collagenase 1), MMP-8 (neutrophil collagenase 2), MMP-13 (collagenase 3) and MMP-18 (collagenase 4).
El objetivo fue correlacionar los niveles de MMP-8 en liquido crevicular gingival con los hallazgos clinicos de la enfermedad periodontal.
Alterations in serum MMP-8, MMP-9, IL-12p40 and IL-23 in multiple sclerosis patients treated with interferon-[beta]1b," Multiple Sclerosis, vol.
Collagenases (MMP-1, MMP-8, and MMP-13) and stromelysins (MMP-3, MMP-10, and MMP11) are composed of a catalytic domain and a hemopexin-like domain.
Their research revealed that an enzyme called MMP-8 (matrix metalloproteinase-8) could be acting as a locator to the immune system, which then becomes activated to attack tumours.
As MMPs pertencem a classe metalo, dependem de zinco para a sua acao catalitica e sao classificadas em cinco grupos: colagenases (MMP-1, MMP-8, MMP-13, MMP-18), gelatinases (MMP-2 e MMP-9), estromalisinas (MMP-3, MMP-10, MMP-11), MMPs tipo membrana (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, MMP-25) e outros (MMP-7, MMP-12, MMP-20 e MMP-26) (Tabela 1) (9, 12, 13).
Results: Significantly elevated levels of MMP-8 and MMP-9 were found in subjects with advanced periodontitis with Random Forest importance scores of 7.
MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP12, and MMP-13 were simultaneously measured using the Fluorokine MultiAnalyte Profiling assays (R&D Systems) on a Luminex 100 Bioanalyzer (Luminex.
Assessment of blood MMP-8 content in patients with urinary bladder carcinoma did not reveal any relationship between enzyme amount and degree of local advancement, malignancy, and the formation of distant metastases [11].
The presence of the MMP-3, MMP-8, and MMP-9 in cartilage appears to be characteristic of pathologic circumstances only.