During the current study, the team led by researchers from the National Human Genome Research Institute (NHGRI) have found that MMP-8
actually serves as a tumour suppressor gene in melanoma, which is why may not be wise to block all MMPs in skin cancer patients with mutation in this gene.
has been linked to MIAC [5-7], inflammation [8-10], histological chorioamnionitis (HCA) , and adverse neonatal outcome [12, 13].
, and MMP-13 are collagenases that cleave types I and III collagen fibers (14).
Wells et al., "Alterations in serum MMP-8
, MMP-9, IL-12p40 and IL-23 in multiple sclerosis patients treated with interferon-[beta]1b," Multiple Sclerosis, vol.
Seven matrix metalloproteinases have been shown to be expressed under varying circumstances in articular cartilage--matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-8 (MMP-8
), matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-13 (MMP-13), and matrix metalloproteinase-14 (MMP-14).
MMPs can be divided into 4 main subtypes: collagenases (MMP-1, MMP-8
, and MMP13), stromelysins (MMP-3, MMP-10, and MMP-11), gelatinases (MMP-2 and MMP-9), and membrane-type matrix metalloproteinases (MT-MMP, MMP-14, MMP-15, MMP16, MMP-17, MMP-24, and MMP-25) .
Collagenases including MMP-1, MMP-8
, MMP-13, and MMP-18 cleave interstitial collagen type I, II, and III and digest some of other ECM and non-ECM proteins.
The plasma levels of MMP-1 (p = 0.002), MMP-8
(p = 0.001), MMP-10 (p = 0.001), MMP-12 (p = 0.002) and MMP-13 (p = 0.006) showed statistically significant increase in OSCC patients as compared to controls.
Pettilaet al., "Serum MMP-8
, -9 and TIMP-1 in sepsis: high serum levels of MMP-8
and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study.
The first one includes so-called collagenases, such as MMP-1 (interstitial, fibroblast collagenase 1), MMP-8
(neutrophil collagenase 2), MMP-13 (collagenase 3) and MMP-18 (collagenase 4).
can promote the invasion and metastasis of ovarian cancer cell via up-regulation of IL-1 p (31).
El objetivo fue correlacionar los niveles de MMP-8
en liquido crevicular gingival con los hallazgos clinicos de la enfermedad periodontal.