MMP8

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MMP8

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 8, which degrades fibrillar type I, II and III collagens. It is involved in breaking down extracellular the matrix in physiological processes—e.g., embryonic development, reproduction, tissue remodelling and wound healing. It differs from most MMP family members in that it is stored in secondary granules within neutrophils and activated by autolytic cleavage.

Molecular pathology
Defects in MMP8 have been linked to arthritis and metastasis.
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References in periodicals archive ?
During the current study, the team led by researchers from the National Human Genome Research Institute (NHGRI) have found that MMP-8 actually serves as a tumour suppressor gene in melanoma, which is why may not be wise to block all MMPs in skin cancer patients with mutation in this gene.
MMP-8 has been linked to MIAC [5-7], inflammation [8-10], histological chorioamnionitis (HCA) [11], and adverse neonatal outcome [12, 13].
MMP1, MMP-8, and MMP-13 are collagenases that cleave types I and III collagen fibers (14).
Wells et al., "Alterations in serum MMP-8, MMP-9, IL-12p40 and IL-23 in multiple sclerosis patients treated with interferon-[beta]1b," Multiple Sclerosis, vol.
Seven matrix metalloproteinases have been shown to be expressed under varying circumstances in articular cartilage--matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-8 (MMP-8), matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-13 (MMP-13), and matrix metalloproteinase-14 (MMP-14).
MMPs can be divided into 4 main subtypes: collagenases (MMP-1, MMP-8, and MMP13), stromelysins (MMP-3, MMP-10, and MMP-11), gelatinases (MMP-2 and MMP-9), and membrane-type matrix metalloproteinases (MT-MMP, MMP-14, MMP-15, MMP16, MMP-17, MMP-24, and MMP-25) [6].
Collagenases including MMP-1, MMP-8, MMP-13, and MMP-18 cleave interstitial collagen type I, II, and III and digest some of other ECM and non-ECM proteins.
The plasma levels of MMP-1 (p = 0.002), MMP-8 (p = 0.001), MMP-10 (p = 0.001), MMP-12 (p = 0.002) and MMP-13 (p = 0.006) showed statistically significant increase in OSCC patients as compared to controls.
Pettilaet al., "Serum MMP-8, -9 and TIMP-1 in sepsis: high serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study.
The first one includes so-called collagenases, such as MMP-1 (interstitial, fibroblast collagenase 1), MMP-8 (neutrophil collagenase 2), MMP-13 (collagenase 3) and MMP-18 (collagenase 4).
MMP-8 can promote the invasion and metastasis of ovarian cancer cell via up-regulation of IL-1 p (31).
El objetivo fue correlacionar los niveles de MMP-8 en liquido crevicular gingival con los hallazgos clinicos de la enfermedad periodontal.