MMP3

(redirected from MMP-3)

MMP3

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 3, which degrades fibronectin, laminin, collagens III, IV, IX and X, and cartilage proteoglycans. MMP3 is thought to be involved in wound repair, progression of atherosclerosis, and tumour initiation.
 
Molecular pathology
Defects in MMP3 cause susceptibility to coronary heart disease type 6.
References in periodicals archive ?
The fourth group comprises stromelysins: MMP-3 (stromelysin 1), MMP-10 (stromelysin 2) and MMP-11 (stromelysin 3).
On the other hand, MMP-3 and MMP-9 are the main inducible MMPs involved in the subacute (24-72 hours after the onset) event of hypoxia/ischemia.
The presence of the MMP-3, MMP-8, and MMP-9 in cartilage appears to be characteristic of pathologic circumstances only.
13) A study which investigated the association between serum levels of MMP-3, macrophage colony stimulating factors, and disease activity showed that these molecules are more useful than C-reactive proteins (CRP) and erythrocyte sedimentation rate (ESR) in predicting disease activity in AS.
Incluyen tambien la MMP-3, -10 y -11, el grupo de matrilisinas que carece del dominio de hemopexina y al cual pertenecen la MMP-7 y -26 (31,32).
MMP-3 and MMP-8 levels in patients with chronic periodontitis before and after nonsurgical periodontal therapy.
It was found that LbGp decreased the level of MMP (matrix metalloproteinase)-1 significantly, but not that of MMP-3 or -13, in the whole human skin system, without compromising the viability of the skin.
Em corneas ulceradas em "melting" provenientes de pacientes com sindrome primaria de Sjogren's, doenca sistemica auto-imune caracterizada pela destruicao de glandulas lacrimais e salivares, observou-se um aumento intenso na expressao de MMP-1, 2, 7 e 9, e um aumento moderado de MMP-3 e 8 no epitelio.
Regulated Expression of Collagenases MMP-1,-8, and-13 aStromelysins MMP-3,-10, and -11 by Human Corneal Epithelial Cells.
MMP-2 (gelatinase A) acts on denatured collagen and gelatin, and MMP-3 (stromelysin) has proteoglycan degrading activity.
UV irradiation activates MAP kinase signaling, which in turn induces transcription factor AP-1, which stimulates expression of matrix metalloproteinases (MMP) including MMP-1 and MMP-3 (Brenneisen et al.
MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP12, and MMP-13 were simultaneously measured using the Fluorokine MultiAnalyte Profiling assays (R&D Systems) on a Luminex 100 Bioanalyzer (Luminex.