Depending on the substrate specificity and structure, MMPs are divided into several subgroups: collagenases (e.g., MMP-1), gelatinases (e.g., MMP-2 and MMP-9), stromelysins (e.g., MMP-3 and MMP-10), matrilysins (e.g., MMP-7 and MMP-26
), and membrane-type matrix metalloproteinase-1 (MT1-MMP).
Matrilysins includes MMP-7 (matrilysin 1) and MMP-26 (matrilysin 2).
That domain is absent in MMP-7, MMP-23 and MMP-26 .
Korkiamaki et al., "Collagenase-2 (MMP8) and matrilysin-2 (MMP-26
) expression in human wounds of different etiologies," Wound Repair and Regeneration, vol.
They are classified according to their substrate specificity, sequence similarity, and domain organization into six groups: collagenases (MMP-1, MMP8, MMP-13, and MMP-18), gelatinases (MMP-2, MMP9), stromelysins (MMP-3, MMP-10), matrilysins (MMP7, MMP-26
), membrane-type MMPs (MMP-14, MMP-15, MMP-16, MMP-24, MMP-17, and MMP-25), and other MMPs (MMP-12, MMP-19, MMP-20, MMP-21, MMP-23, MMP-27, and MMP-28) .
Based on their domain structure and substrate preference, MMPs are traditionally grouped into (1) collagenases, including MMP-1, -8, -13; (2) stromelysins, MMP-3 and MMP-10; (3) gelatinases, MMP-2 and MMP-9; (4) matrilysins, MMP-7 and MMP-26
; (5) membrane-type MMPs (MT-MMPs); and others (Table 1) 28].
Matrilysins which lack hemopexin domain include MMP-7 (matrilysin-1) and MMP-26
As MMPs pertencem a classe metalo, dependem de zinco para a sua acao catalitica e sao classificadas em cinco grupos: colagenases (MMP-1, MMP-8, MMP-13, MMP-18), gelatinases (MMP-2 e MMP-9), estromalisinas (MMP-3, MMP-10, MMP-11), MMPs tipo membrana (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, MMP-25) e outros (MMP-7, MMP-12, MMP-20 e MMP-26) (Tabela 1) (9, 12, 13).
Grupo Colagenases MMP Nome enzimatico MMP-1 Colagenase intersticial MMP-8 Neutrofilo colagenase MMP-13 Colagenase-3 Gelatinases MMP-2 Gelatinase A MMP-9 Gelatinase B Estromalisinas MMP-3 Estromalisina-1 MMP-10 Estromalisina-2 MMP-11 Estromalisina-3 MMPs tipo MMP-14 MT1-MMP membrana MMP-16 MT3-MMP MMP-17 MT4-MMP MMP-24 MT5-MMP MMP-25 MT6-MMP Outras MMP-7 Matrilisina MMP-26 Matrilisina-2 MMP-12 Macrofago metaloelastase