MMP2

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MMP2

A gene on chromosome 16q13-q21 that encodes matrix metalloproteinase 2, a ubiquitinous metalloproteinase that degrades type-IV collagen and is involved in remodelling vasculature, endometrial menstrual breakdown, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture.

Molecular pathology
MMP2 mutations cause Torg-Winchester syndrome and nodulosis-arthropathy-osteolysis syndrome.
References in periodicals archive ?
The pro-domains structure of MMP-1, MMP-2, MMP-3 and MMP-9 has been well determined.
sup][9],[10] MMP-2 is the most commonly expressed enzyme to degrade collagen, elastin, and fibronectin.
On the contrary, the implication of MMP-2 in the pathogenesis of MS is more controversial, since this enzyme had demonstrated both protective [7] and detrimental actions [14].
Both MMP-2 and MMP-9 were shown to locate in the Golgi and trans-Golgi network both in nonreactive and in reactive astrocytes [28].
Estos poseen la capacidad de inhibir todas las MMP, entre los cuales TIMP-1 es el preferente inhibidor de MMP-9 y TIMP-2 lo es de MMP-2.
A correlation between the presence of MMP-2 in synovial fluid from patients with TMD and the degeneration of disc and articular cartilage has been reported (13).
2003) demonstrated for the first time the involvement of MMP-2 and MMP-9 in canine tumors as well as the relation of such proteins with the different tumoral levels.
It is believed that a very important function of MMP-2 and MMP-9 is in cell remodeling processes in the male and female reproductive system (Woessner, 1994; Hulboy et al.
A MT1-MMP (MMP14) e a melhor caracterizada, e e responsavel pela ativacao da MMP-2 pela sua interacao com a TIMP-2, alem de atividades proteoliticas pericelulares (16).