MMP2

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MMP2

A gene on chromosome 16q13-q21 that encodes matrix metalloproteinase 2, a ubiquitinous metalloproteinase that degrades type-IV collagen and is involved in remodelling vasculature, endometrial menstrual breakdown, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture.

Molecular pathology
MMP2 mutations cause Torg-Winchester syndrome and nodulosis-arthropathy-osteolysis syndrome.
References in periodicals archive ?
However, the median serum level of MMP-2 was statistically higher in controls as compared to OSCC patients thereby giving idea about some feedback regulation.
The matrix metalloproteinases (MMPs) play an important role in the process of cardiac remodeling by regulating structural integrity of the extracellular matrix.[9] MMP-2 is one of the predominant MMPs expressed in the cardiac ventricles.
(a) MMP-2 activation: to obtain active MMP-2, 80 [micro]l of 0.7 mg/ml mouse MMP2/Tris-HCl solution was mixed with 0.1 ml of 2.5 mmol/l4-aminophenylmercuric acetate (APMA) and incubated for 2 h in a 37[degrees]C water bath.
Grzela, "Modulation of matrix metalloproteinases MMP-2 and MMP-9 activity by hydrofiber-foam hybrid dressing--Relevant support in the treatment of chronic wounds," Central European Journal of Immunology, vol.
Neth, "MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines," Blood, vol.
The pro-domains structure of MMP-1, MMP-2, MMP-3 and MMP-9 has been well determined.
They are a family of zinc-containing enzymes capable of degrading components of ECM and connective tissues.[sup][9],[10] MMP-2 is the most commonly expressed enzyme to degrade collagen, elastin, and fibronectin.[sup][11] Clinical studies revealed that the attenuation of MMP-2 expression was observed in plasma from patients with hypertension.[sup][12] Animal investigations from adult spontaneously hypertensive rats (SHRs) also indicated that pro-MMP2 and activated MMP-2 activities were diminished in mesenteric arteries, contributing to accumulation of collagen and fibronectin.[sup][13] The remodeling of large and small arteries may be the major causes of the development of ECM accumulation and hypertension.[sup][14]
The intensity of positive staining for collagen type I, MMP-2, and MMP-9 was measured using Image-Proplus 6.0 software (Media Cybernetics, United States).
In the present study, we determined whether PNU-282987, a selective [alpha]7-nAChR agonist, affected activities of MMP-2 and MMP-9 and expressions of inflammatory cytokines MCP-1 and RANTES in nicotine treatment RAW264.7 and MOVAS cells.