MMP2

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MMP2

A gene on chromosome 16q13-q21 that encodes matrix metalloproteinase 2, a ubiquitinous metalloproteinase that degrades type-IV collagen and is involved in remodelling vasculature, endometrial menstrual breakdown, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture.

Molecular pathology
MMP2 mutations cause Torg-Winchester syndrome and nodulosis-arthropathy-osteolysis syndrome.

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References in periodicals archive ?

9] MMP-2 is one of the predominant MMPs expressed in the cardiac ventricles.

Differences of Matrix Metalloproteinase 2 Expression between Left and Right Ventricles in Response to Nandrolone Decanoate and/or Swimming Training in Mice

The pro-domains structure of MMP-1, MMP-2, MMP-3 and MMP-9 has been well determined.

Matrix metalloproteinases in urinary system tumours. Part I - Matrix metalloproteinases in renal cell carcinoma

sup][9],[10] MMP-2 is the most commonly expressed enzyme to degrade collagen, elastin, and fibronectin.

Estrogen deficiency modifies matrix metalloproteinases activity and vascular function of mesenteric arteries in female rats

On the contrary, the implication of MMP-2 in the pathogenesis of MS is more controversial, since this enzyme had demonstrated both protective [7] and detrimental actions [14].

Interplay between matrix metalloproteinase-9, matrix metalloproteinase-2, and interleukins in multiple sclerosis patients

Both MMP-2 and MMP-9 were shown to locate in the Golgi and trans-Golgi network both in nonreactive and in reactive astrocytes [28].

Oxidative DNA Damage Mediated by Intranuclear MMP Activity Is Associated with Neuronal Apoptosis in Ischemic Stroke

SalA holds stronger activity on MMP-2, MMP-8 and MMP-9 than Dox, except on MMP-13 (Table 1).

Salvianolic acid A, a matrix metalloproteinase-9 inhibitor of Salvia miltiorrhiza, attenuates aortic aneurysm formation in apolipoprotein E-deficient mice

Estos poseen la capacidad de inhibir todas las MMP, entre los cuales TIMP-1 es el preferente inhibidor de MMP-9 y TIMP-2 lo es de MMP-2.

Expresion de metaloproteinasas en el proceso de palatogenesis: revision sistematica de la literatura

A correlation between the presence of MMP-2 in synovial fluid from patients with TMD and the degeneration of disc and articular cartilage has been reported (13).

Expression of MMP-2 and MMP-9 in the rat trigeminal ganglion during the development of temporomandibular joint inflammation

2003) demonstrated for the first time the involvement of MMP-2 and MMP-9 in canine tumors as well as the relation of such proteins with the different tumoral levels.

Matrix metalloproteinases 2 and 9 expression in canine normal prostate and with proliferative disorders/Expressao de metaloproteinases de matriz 2 e 9 na prostata canina normal e com lesoes proliferativas

MMP-2 and MMP-9 are the most widely spread representatives of MMP family.

Assessment of activity of matrix metalloproteases 2 and 9 in their interconnection with the level of magnesium ions in the blood of patients with congenital prolapsed of mitral valve

It is believed that a very important function of MMP-2 and MMP-9 is in cell remodeling processes in the male and female reproductive system (Woessner, 1994; Hulboy et al.

Effects of hormones on the expression of matrix metalloproteinases and their inhibitors in bovine spermatozoa

A MT1-MMP (MMP14) e a melhor caracterizada, e e responsavel pela ativacao da MMP-2 pela sua interacao com a TIMP-2, alem de atividades proteoliticas pericelulares (16).

Matrix metalloproteinases in corneal repair. Review/Matriz metaloproteinases na reparacao corneal. Revisao de literatura/Metaloproteinasas de matriz en la reparacion de la cornea. Revision de literatura