MMP2

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MMP2

A gene on chromosome 16q13-q21 that encodes matrix metalloproteinase 2, a ubiquitinous metalloproteinase that degrades type-IV collagen and is involved in remodelling vasculature, endometrial menstrual breakdown, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture.

Molecular pathology
MMP2 mutations cause Torg-Winchester syndrome and nodulosis-arthropathy-osteolysis syndrome.

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References in periodicals archive ?

However, the median serum level of MMP-2 was statistically higher in controls as compared to OSCC patients thereby giving idea about some feedback regulation.

Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma

GPNMB regulated the expression and activity of MMP-2 and MMP-9 in cervical cancer cells

Glycoprotein nonmetastatic melanoma protein B accelerates tumorigenesis of cervical cancer in vitro by regulating the Wnt/[beta]-catenin pathway

In male reproductive system, MMP-2 and MMP-9 are detected in seminal plasma.

Activity of Matrix Metalloproteinase 2 and 9 in Follicular Fluid and Seminal Plasma and Its Relation to Embryo Quality and Fertilization Rate

The matrix metalloproteinases (MMPs) play an important role in the process of cardiac remodeling by regulating structural integrity of the extracellular matrix.[9] MMP-2 is one of the predominant MMPs expressed in the cardiac ventricles.

Differences of Matrix Metalloproteinase 2 Expression between Left and Right Ventricles in Response to Nandrolone Decanoate and/or Swimming Training in Mice

There is a higher prevalence of studies on MMP-2 and MMP-9.

Diagnosis and Prognosis of Prostate Cancer from Circulating Matrix Metalloproteinases and Inhibitors

(a) MMP-2 activation: to obtain active MMP-2, 80 [micro]l of 0.7 mg/ml mouse MMP2/Tris-HCl solution was mixed with 0.1 ml of 2.5 mmol/l4-aminophenylmercuric acetate (APMA) and incubated for 2 h in a 37[degrees]C water bath.

Construction and Evaluation of the Tumor-Targeting, Cell-Penetrating Multifunctional Molecular Probe iCREKA

Grzela, "Modulation of matrix metalloproteinases MMP-2 and MMP-9 activity by hydrofiber-foam hybrid dressing--Relevant support in the treatment of chronic wounds," Central European Journal of Immunology, vol.

Wound Fluid Matrix Metalloproteinase-9 as a Potential Predictive Marker for the Poor Healing Outcome in Diabetic Foot Ulcers

Neth, "MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines," Blood, vol.

IL-1[beta]-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway

The pro-domains structure of MMP-1, MMP-2, MMP-3 and MMP-9 has been well determined.

Matrix metalloproteinases in urinary system tumours. Part I - Matrix metalloproteinases in renal cell carcinoma

They are a family of zinc-containing enzymes capable of degrading components of ECM and connective tissues.[sup][9],[10] MMP-2 is the most commonly expressed enzyme to degrade collagen, elastin, and fibronectin.[sup][11] Clinical studies revealed that the attenuation of MMP-2 expression was observed in plasma from patients with hypertension.[sup][12] Animal investigations from adult spontaneously hypertensive rats (SHRs) also indicated that pro-MMP2 and activated MMP-2 activities were diminished in mesenteric arteries, contributing to accumulation of collagen and fibronectin.[sup][13] The remodeling of large and small arteries may be the major causes of the development of ECM accumulation and hypertension.[sup][14]

Estrogen deficiency modifies matrix metalloproteinases activity and vascular function of mesenteric arteries in female rats

The intensity of positive staining for collagen type I, MMP-2, and MMP-9 was measured using Image-Proplus 6.0 software (Media Cybernetics, United States).

The Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Anterior Segment

In the present study, we determined whether PNU-282987, a selective [alpha]7-nAChR agonist, affected activities of MMP-2 and MMP-9 and expressions of inflammatory cytokines MCP-1 and RANTES in nicotine treatment RAW264.7 and MOVAS cells.

Stimulation of Alpha7 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Upregulation of MMP, MCP-1, and RANTES through Modulating ERK1/2/AP-1 Signaling Pathway in RAW264.7 and MOVAS Cells