MMP19

(redirected from MMP-18)

MMP19

A gene on chromosome 12q14 that encodes matrix metalloproteinase 19, an endopeptidase that degrades components of the extracellular matrix, including collagen IV, laminin, nidogen, nascin-C isoform, fibronectin and type I gelatin, playing a role in development, haemostasis and pathological conditions (e.g., arthritic disease). It is widely expressed except in the brain and peripheral white cells.
References in periodicals archive ?
The first one includes so-called collagenases, such as MMP-1 (interstitial, fibroblast collagenase 1), MMP-8 (neutrophil collagenase 2), MMP-13 (collagenase 3) and MMP-18 (collagenase 4).
Studies on neutrophil collagenase and MMP-18 in clear cell renal cell carcinoma did not demonstrate any increase in their activity in primary tumour tissue or metastases as compared to normal tissue [3,32].
Expression of MMP-18 in bladder cancers and its effect on the course of the disease are unknown.