MMP19

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MMP19

A gene on chromosome 12q14 that encodes matrix metalloproteinase 19, an endopeptidase that degrades components of the extracellular matrix, including collagen IV, laminin, nidogen, nascin-C isoform, fibronectin and type I gelatin, playing a role in development, haemostasis and pathological conditions (e.g., arthritic disease). It is widely expressed except in the brain and peripheral white cells.
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References in periodicals archive ?
The first one includes so-called collagenases, such as MMP-1 (interstitial, fibroblast collagenase 1), MMP-8 (neutrophil collagenase 2), MMP-13 (collagenase 3) and MMP-18 (collagenase 4).
They are classified according to their substrate specificity, sequence similarity, and domain organization into six groups: collagenases (MMP-1, MMP8, MMP-13, and MMP-18), gelatinases (MMP-2, MMP9), stromelysins (MMP-3, MMP-10), matrilysins (MMP7, MMP-26), membrane-type MMPs (MMP-14, MMP-15, MMP-16, MMP-24, MMP-17, and MMP-25), and other MMPs (MMP-12, MMP-19, MMP-20, MMP-21, MMP-23, MMP-27, and MMP-28) [11].
Collagenases including MMP-1, MMP-8, MMP-13, and MMP-18 cleave interstitial collagen type I, II, and III and digest some of other ECM and non-ECM proteins.
As MMPs pertencem a classe metalo, dependem de zinco para a sua acao catalitica e sao classificadas em cinco grupos: colagenases (MMP-1, MMP-8, MMP-13, MMP-18), gelatinases (MMP-2 e MMP-9), estromalisinas (MMP-3, MMP-10, MMP-11), MMPs tipo membrana (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, MMP-25) e outros (MMP-7, MMP-12, MMP-20 e MMP-26) (Tabela 1) (9, 12, 13).
Expression of MMP-18 in bladder cancers and its effect on the course of the disease are unknown.