MMP16

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MMP16

A gene on chromosome 8q21.3 that encodes matrix metalloproteinase 16, an endopeptidase that degrades components of the extracellular matrix, including collagen III and fibronectin, and activates progelatinase A. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP16 is a transmembrane protein that is activated from its precursor by furin endopeptidase cleavage. It is expressed in the heart, brain, placenta, ovaries and small intestine.

Molecular pathology
Interaction of MMP16 and CSPG4 may trigger degradation and invasion of type-I collagen by melanomas.
References in periodicals archive ?
Four of them are classified as type I membrane proteins, MMP-14, MMP-15, MMP-16 and MMP-24, while remaining two (MMP-17 and MMP-25) are attached to the membrane by glycosylphosphatidylinositol molecule.
Transmembrane metalloproteinases, MMP-14,MMP-15 and MMP-16 were considered to be expressed to a significant level in the course of renal cell carcinoma in tumour-modified tissue and present in urine samples collected from the same patients [51].
Membrane type MMPs (MT-MMP) (MMP-14, MMP-15, MMP-16, MMP-17, MMP24, and MMP-25) are anchored to the plasma membrane by a transmembrane domain with a cytoplasmic domain or a glycosylphosphatidylinositol (GPI).
As MMPs pertencem a classe metalo, dependem de zinco para a sua acao catalitica e sao classificadas em cinco grupos: colagenases (MMP-1, MMP-8, MMP-13, MMP-18), gelatinases (MMP-2 e MMP-9), estromalisinas (MMP-3, MMP-10, MMP-11), MMPs tipo membrana (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, MMP-25) e outros (MMP-7, MMP-12, MMP-20 e MMP-26) (Tabela 1) (9, 12, 13).