MMP14

(redirected from MMP-14)

MMP14

A gene on chromosome 14q11-q12 that encodes matrix metalloproteinase 14, which specifically activates progelatinase A. It may be involved in actin cytoskeleton reorganisation by cleaving PTK7. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP14 is a transmembrane protein that is activated from its precursor by furin endopeptidase cleavage.

Molecular pathology
MMP14 may trigger invasion by tumour cells by activating progelatinase A on the surface of tumour cells.
Mentioned in ?
References in periodicals archive ?
Four of them are classified as type I membrane proteins, MMP-14, MMP-15, MMP-16 and MMP-24, while remaining two (MMP-17 and MMP-25) are attached to the membrane by glycosylphosphatidylinositol molecule.
Transmembrane metalloproteinases, MMP-14,MMP-15 and MMP-16 were considered to be expressed to a significant level in the course of renal cell carcinoma in tumour-modified tissue and present in urine samples collected from the same patients [51].
sup][51] Vulnerable plaque formation risk was significantly decreased in carotid plaque with MMP-14 position + 7096 TC + CC genotype compared to that in carotid plaque with MMP-14 TT genotype.
showed single bout exercise was significantly increased MMP9 and vascular endothelial growth factor-A (VEGF-A)mRNA level of muscle biopsy but no significant effect on MMP2 and MMP-14 mRNA levels of muscle biopsy.
In line with this hypothesis, a recent in vitro study on neuron-like cells reported an upregulation of MMP-14, the physiological activator of MMP-2, upon treatment with increasing amounts of IL-18 [42].
Grupo Colagenases MMP Nome enzimatico MMP-1 Colagenase intersticial MMP-8 Neutrofilo colagenase MMP-13 Colagenase-3 Gelatinases MMP-2 Gelatinase A MMP-9 Gelatinase B Estromalisinas MMP-3 Estromalisina-1 MMP-10 Estromalisina-2 MMP-11 Estromalisina-3 MMPs tipo MMP-14 MT1-MMP membrana MMP-16 MT3-MMP MMP-17 MT4-MMP MMP-24 MT5-MMP MMP-25 MT6-MMP Outras MMP-7 Matrilisina MMP-26 Matrilisina-2 MMP-12 Macrofago metaloelastase
M2 EQUITYBITES-September 21, 2012-Dyax Corp signs licensing deal with Kadmon for MMP-14 inhibitor(C)2012 M2 COMMUNICATIONS http://www.
M2 PHARMA-September 21, 2012-Dyax Corp signs licensing deal with Kadmon for MMP-14 inhibitor(C)2012 M2 COMMUNICATIONS
In cardiac myocytes, ANG signals mechanical stress to induce MMP-2 and MMP-14 genes expression via JNK-STAT pathway (9).
An increase of MMP-14 content in bladder tumor tissue, in comparison with normal tissue, was demonstrated [30].
Of those seven, four have been found to be constitutively expressed in adult cartilage, presumably serving roles in tissue turnover, and upregulated in diseased states--MMP-1, MMP-2, MMP-13, and MMP-14 [3].