MMP13

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MMP13

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 13, which cleaves collagens I in the extracellular matrix. MMP13 may play a role in turnover of articular cartilage.

Molecular pathology
Defects in MMP13 cause spondyloepimetaphyseal dysplasia Missouri type and metaphyseal anadysplasia type 1. MMP13 may play a role in the pathogenesis of osteoarthritis.
References in periodicals archive ?
The first one includes so-called collagenases, such as MMP-1 (interstitial, fibroblast collagenase 1), MMP-8 (neutrophil collagenase 2), MMP-13 (collagenase 3) and MMP-18 (collagenase 4).
Plasma levels of E-cadherin and MMP-13 in prostate cancer patients: correlation with PSA, testosterone and pathological parameters.
Overexpression of MMP-13 gene in colorectal cancer with liver metastasis.
Morris y colaboradores (23,24), en estadios posteriores (E12, E13 y E14), describieron la distribucion temporoespacial de MMP-2, MMP-3, MMP-9 y MMP-13 en las crestas palatinas durante el curso de la palatogenesis in vivo en el raton.
There appears to be strong inhibition of iNOS, MMP-9, MMP-13, NF-[kappa]B, TNF[alpha], IL-1, IL-2, IL-4, IL-6, and IFN[gamma], and the complement system.
A recent study in IL-1[beta]-treated human chondrocytes found that this compound inhibited the expression of MMP-1, MMP-3, and MMP-13 while increasing the mRNA expression of the natural inhibitors of these enzymes is called tissue inhibitors of matrix metalloproteinase (TIMP) via the NF-kB signaling pathway [12].
As MMPs pertencem a classe metalo, dependem de zinco para a sua acao catalitica e sao classificadas em cinco grupos: colagenases (MMP-1, MMP-8, MMP-13, MMP-18), gelatinases (MMP-2 e MMP-9), estromalisinas (MMP-3, MMP-10, MMP-11), MMPs tipo membrana (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, MMP-25) e outros (MMP-7, MMP-12, MMP-20 e MMP-26) (Tabela 1) (9, 12, 13).
7) MMP-13 (which stands for matrix metalloproteinase-13) dissolves cartilage, leaving the joint space unprotected and vulnerable to friction and traumatic injury.