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The gene expression of MMP-9 and MMP-12 of the heart grafts was strikingly higher than that measured in the native hearts.
Gene expression of TNF-[alpha] (A), MCP-1 (B), IL-18 (C), VCAM-1 (D), IL-10 (E), IL-1b (F), MMP-9 (G), MMP-12 (H), LDLR (I), LRP-1 (J), CD-36 (K), in control native and grafted hearts, and LDE-MTX grafted hearts of the rabbits.
MMP-12 (metalloelastase) is expressed mostly in macrophages and is responsible for their migration.
Concerning other metalloproteinases, it has been demonstrated that MMP-12 is expressed in renal cell carcinoma tissue [52].
The overexpression of MMP-7, MMP-10, and MMP-12 in colon cancer patients' sera correlates with a dismal prognosis [7] and high serum MMP-1 level showed a trend for short overall survival in non-small cell lung cancer patients [8].
As MMPs pertencem a classe metalo, dependem de zinco para a sua acao catalitica e sao classificadas em cinco grupos: colagenases (MMP-1, MMP-8, MMP-13, MMP-18), gelatinases (MMP-2 e MMP-9), estromalisinas (MMP-3, MMP-10, MMP-11), MMPs tipo membrana (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, MMP-25) e outros (MMP-7, MMP-12, MMP-20 e MMP-26) (Tabela 1) (9, 12, 13).
Grupo Colagenases MMP Nome enzimatico MMP-1 Colagenase intersticial MMP-8 Neutrofilo colagenase MMP-13 Colagenase-3 Gelatinases MMP-2 Gelatinase A MMP-9 Gelatinase B Estromalisinas MMP-3 Estromalisina-1 MMP-10 Estromalisina-2 MMP-11 Estromalisina-3 MMPs tipo MMP-14 MT1-MMP membrana MMP-16 MT3-MMP MMP-17 MT4-MMP MMP-24 MT5-MMP MMP-25 MT6-MMP Outras MMP-7 Matrilisina MMP-26 Matrilisina-2 MMP-12 Macrofago metaloelastase
com)-- AnaSpec has announced the release of three new MMP recombinant proteins, MMP-1, MMP-9 and MMP-12.
It also inhibited the protease MMP-12, which is known as one of the main enzymes able to destroy lung tissue.
MMP-12 and MMP-13 could not be determined because the measurements gave signals below the detection limit.
Bronchoalveolar lavage samples from human subjects with COPD associated with wood-smoke exposure demonstrated significantly higher MMP activity, specifically proMMP-2, pro-MMP-9, and MMP-9, and gene expression of MMP-2 and MMP-12, when compared with healthy controls (Montano et al.