matrix metalloproteinase-11

(redirected from MMP-11)

matrix metalloproteinase-11

A matrix metalloproteinase encoded on chromosome 22q11.2 which degrades extracellular matrix, collagens and other tissue substrates.

Cytokine inducers
EGF, FGF-b, IGF-II, IL-6, PDGF, TGF-alpha.
 
Substrates
Alpha1-antitrypsin, alpha2-macroglobulin, casein, IGF-binding protein-1.

Normal expression
Increased expression and activation during wound healing; migration and extracellular matrix remodeling is accompanied by acquisition of a mesenchymal phenotype in respiratory epithelial cells.

Abnormal expression
MMP-11 appears in the desmoplastic stroma of invasive, but not in situ, breast carcinoma; its transcription may be induced by diffusible cytokines (e.g., PDGF, fibroblast growth factor, TGF-alpha), providing a mechanism by which malignant cells destroy basement membranes and invade tissues.
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References in periodicals archive ?
Elevated serum levels of MMP-11 correlate with poor prognosis in colon cancer patients.
Role of immunohistochemical overexpression of matrix metalloproteinases MMP-2 and MMP-11 in the prognosis of death by ovarian cancer.
The fourth group comprises stromelysins: MMP-3 (stromelysin 1), MMP-10 (stromelysin 2) and MMP-11 (stromelysin 3).
However, MMP-1, MMP-8, MMP-9, MMP-10, MMP-11, TIMP-1, and TIMP-2 genes were not altered by antcin-H (data not shown).
According to their main substrate specificity, MMPs can be divided into collagenases (MMP-1, MMP-8, and MMP-13), gelatinases (MMP-2 and MMP-9), stromelysins (MMP-3, MMP-10, and MMP-11), and membrane type I MMPs (MMP-14-17).
Metalloproteinases include cell membrane metalloproteinases which are related to cell membrane (MMP-14, MMP-15, MMP-16, and MMP-17), gelatinases (MMP-2 and MMP-9), stromelysins (MMP-3, MMP-7, MMP-10, MMP-11, and MMP-12), and collagenases (MMP-1, MMP-8, and MMP-13).
MMP2, MMP7, MMP11 absence results in carcinogenesis inhibition; the lack of MMP9 results in reduced metastatic process and MMP-11 absence stimulates the metastatic mechanism [23, 109, 110].
Thorns, "Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas," Anticancer Research, vol.
MMPs can be divided into 4 main subtypes: collagenases (MMP-1, MMP-8, and MMP13), stromelysins (MMP-3, MMP-10, and MMP-11), gelatinases (MMP-2 and MMP-9), and membrane-type matrix metalloproteinases (MT-MMP, MMP-14, MMP-15, MMP16, MMP-17, MMP-24, and MMP-25) [6].
MMP-8 expression can be used as a good prognostic marker in breast cancer, while MMP-3, MMP-11, and MMP-19 have been found to play dual roles in cancer, and they may exert protumorigenic or suppressor roles depending on the tumor context [30].
As MMPs pertencem a classe metalo, dependem de zinco para a sua acao catalitica e sao classificadas em cinco grupos: colagenases (MMP-1, MMP-8, MMP-13, MMP-18), gelatinases (MMP-2 e MMP-9), estromalisinas (MMP-3, MMP-10, MMP-11), MMPs tipo membrana (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, MMP-25) e outros (MMP-7, MMP-12, MMP-20 e MMP-26) (Tabela 1) (9, 12, 13).
Expression of MMP-10 (stromelysin 2) does not show any relationship with the advancement of bladder carcinoma [28], while expression of MMP-11 was significantly higher and positively correlated with the degree of tumor aggressiveness and malignancy [29].