matrix metalloproteinase-11

(redirected from MMP-11)

matrix metalloproteinase-11

A matrix metalloproteinase encoded on chromosome 22q11.2 which degrades extracellular matrix, collagens and other tissue substrates.

Cytokine inducers
EGF, FGF-b, IGF-II, IL-6, PDGF, TGF-alpha.
 
Substrates
Alpha1-antitrypsin, alpha2-macroglobulin, casein, IGF-binding protein-1.

Normal expression
Increased expression and activation during wound healing; migration and extracellular matrix remodeling is accompanied by acquisition of a mesenchymal phenotype in respiratory epithelial cells.

Abnormal expression
MMP-11 appears in the desmoplastic stroma of invasive, but not in situ, breast carcinoma; its transcription may be induced by diffusible cytokines (e.g., PDGF, fibroblast growth factor, TGF-alpha), providing a mechanism by which malignant cells destroy basement membranes and invade tissues.
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References in periodicals archive ?
The fourth group comprises stromelysins: MMP-3 (stromelysin 1), MMP-10 (stromelysin 2) and MMP-11 (stromelysin 3).
Grupo Colagenases MMP Nome enzimatico MMP-1 Colagenase intersticial MMP-8 Neutrofilo colagenase MMP-13 Colagenase-3 Gelatinases MMP-2 Gelatinase A MMP-9 Gelatinase B Estromalisinas MMP-3 Estromalisina-1 MMP-10 Estromalisina-2 MMP-11 Estromalisina-3 MMPs tipo MMP-14 MT1-MMP membrana MMP-16 MT3-MMP MMP-17 MT4-MMP MMP-24 MT5-MMP MMP-25 MT6-MMP Outras MMP-7 Matrilisina MMP-26 Matrilisina-2 MMP-12 Macrofago metaloelastase
Expression of MMP-10 (stromelysin 2) does not show any relationship with the advancement of bladder carcinoma [28], while expression of MMP-11 was significantly higher and positively correlated with the degree of tumor aggressiveness and malignancy [29].