MMP1

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MMP1

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 1, which cleaves collagens I, II and III in the helical domain, as well as collagens VII and X. MMP1 interacts and cleaves HIV’s secreted Tat protein, reducing neuronal Tat-mediated neurotoxicity.
References in periodicals archive ?
The body needs MMP-1 to help remodel lung tissue (for instance, in wound healing), but if there is too much of the enzyme, it can result in tissue destruction.
The first one includes so-called collagenases, such as MMP-1 (interstitial, fibroblast collagenase 1), MMP-8 (neutrophil collagenase 2), MMP-13 (collagenase 3) and MMP-18 (collagenase 4).
Fibroblasts support migration of monocyte-derived dendritic cells by secretion of PGE2 and MMP-1.
Since 1995, several MMPs have been demonstrated as active proteases localized in nuclei of various human and animal cell types; they are MMP-1, MMP2, MMP-3, MMP-9, MMP-10, MMP-13, MT1-MMP, and MTMMP-2 (MMP-15) [26].
21) reported expression of MMP-1, MMP-2, MMP-3, MMP-9, TIMP-1 and TIMP-2 on both synovial (lining) and subsynovial (sublining) layers.
En otro estudio publicado en el 2007, Letra y colaboradores (46) determinaron los polimorfismos en genes promotores de MMP-1 y MMP-3 asociados con el labio y paladar fisurado no sindromico.
Furthermore, in the presence of LbGp5, these cultures also contained higher levels of the MMP-1 substrate-collagen type I.
To facilitate the mobility of these cells, an enzyme needed to break down collagen, which is the largest component of the extracellular matrix, called collagenase (matrix metalloproteinases/ MMP), such as MMP-1, -8, and -13.
According to the company it is a pomegranate flower-derived, two component-based active that not only promotes collagen synthesis but also decreases the breakdown of collagen by inhibiting MMP-1 production.
It achieved this by reducing the expression of MMP-1, MMP-2, and MMP-7, by blocking MAPK signaling by inhibiting the phosphorylation of ERIC and p38 MAPK, by inhibition of AP-1 activation, and by inducing focal adhesion formation and modulating vinculin localization and expression.
DEP evokes the secretion of matrix metalloproteinase-1 (MMP-1) from human bronchial epithelia, which is important because MMP-1 plays a role in tissue remodeling during respiratory disease processes.