MMP1

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MMP1

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 1, which cleaves collagens I, II and III in the helical domain, as well as collagens VII and X. MMP1 interacts and cleaves HIV’s secreted Tat protein, reducing neuronal Tat-mediated neurotoxicity.
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The body needs MMP-1 to help remodel lung tissue (for instance, in wound healing), but if there is too much of the enzyme, it can result in tissue destruction.
TB bacterium may suppress immune system to spread disease
The first one includes so-called collagenases, such as MMP-1 (interstitial, fibroblast collagenase 1), MMP-8 (neutrophil collagenase 2), MMP-13 (collagenase 3) and MMP-18 (collagenase 4).
Matrix metalloproteinases in urinary system tumours. Part I - Matrix metalloproteinases in renal cell carcinoma
Fibroblasts support migration of monocyte-derived dendritic cells by secretion of PGE2 and MMP-1.
Effect of Matrix Metallopeptidase 13 on the Function of Mouse Bone Marrow-derived Dendritic Cells
Since 1995, several MMPs have been demonstrated as active proteases localized in nuclei of various human and animal cell types; they are MMP-1, MMP2, MMP-3, MMP-9, MMP-10, MMP-13, MT1-MMP, and MTMMP-2 (MMP-15) [26].
Oxidative DNA Damage Mediated by Intranuclear MMP Activity Is Associated with Neuronal Apoptosis in Ischemic Stroke
21) reported expression of MMP-1, MMP-2, MMP-3, MMP-9, TIMP-1 and TIMP-2 on both synovial (lining) and subsynovial (sublining) layers.
Association of matrix metalloproteinases and their tissue inhibitor with disease activity and development in spondyloarthropathy and inflammatory bowel disease
En otro estudio publicado en el 2007, Letra y colaboradores (46) determinaron los polimorfismos en genes promotores de MMP-1 y MMP-3 asociados con el labio y paladar fisurado no sindromico.
Expresion de metaloproteinasas en el proceso de palatogenesis: revision sistematica de la literatura
Furthermore, in the presence of LbGp5, these cultures also contained higher levels of the MMP-1 substrate-collagen type I.
Lycium barbarum glycoconjugates: effect on human skin and cultured dermal fibroblasts
27), corneas de ratos saudaveis tratadas com lagrimas artificiais, nao expressam MMP-1 e MMP-8.
Matrix metalloproteinases in corneal repair. Review/Matriz metaloproteinases na reparacao corneal. Revisao de literatura/Metaloproteinasas de matriz en la reparacion de la cornea. Revision de literatura
To facilitate the mobility of these cells, an enzyme needed to break down collagen, which is the largest component of the extracellular matrix, called collagenase (matrix metalloproteinases/ MMP), such as MMP-1, -8, and -13.
THE DYNAMICS OF GENE EXPRESSION OF MATRIX METALLOPROTEINASE-8 AND TISSUE INHIBITOR METALLOPROTEINASE-1 ON REMOVABLE ORTHODONTIC APPLIANCE WEARERS
According to the company it is a pomegranate flower-derived, two component-based active that not only promotes collagen synthesis but also decreases the breakdown of collagen by inhibiting MMP-1 production.
The latest anti-aging complex from Cosmetochem
It achieved this by reducing the expression of MMP-1, MMP-2, and MMP-7, by blocking MAPK signaling by inhibiting the phosphorylation of ERIC and p38 MAPK, by inhibition of AP-1 activation, and by inducing focal adhesion formation and modulating vinculin localization and expression.
Anti-metastatic effects of ginsenoside Rd via inactivation of MAPK signaling and induction of focal adhesion formation
DEP evokes the secretion of matrix metalloproteinase-1 (MMP-1) from human bronchial epithelia, which is important because MMP-1 plays a role in tissue remodeling during respiratory disease processes.
Diesel exhaust particles and inflammation

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