En otro estudio publicado en el 2007, Letra y colaboradores (46) determinaron los polimorfismos en genes promotores de MMP-1
y MMP-3 asociados con el labio y paladar fisurado no sindromico.
The MMPs can be classified into four major subgroups: collagenases (MMP-1
, MMP-3, and MMP-8), gelatinases (MMP-2, MMP-9), stromelysins (MMP-3, MMP-7, MMP-10, and MMP-12), and membrane-type metalloproteinases (MTMMP-1 through MTMMP-5) .
Resultados semejantes fueron obtenidos por Ingman y col., al analizar muestras de tejido gingival posterior al tratamiento de pacientes con raspado y alisado radicular, encontrado inmunoreactividad para la neutrofilo colagenasa (MMP-8), mientras que para MMP-3 y MMP-1
no detectaron inmunorreactividad al igual que en las muestras de tejido de los pacientes controles, concluyendo que la MMP-8 es la principal colagenasa presente en el tejido gingival de pacientes con PC (15).
, MMP-2 and MMP-9 protein expression as significant prognostic factors in human prostate cancer.
Consistently, LbGp inhibited skin expansion under mechanical stress, which in this model depends on the activity of MMP-1
. We found that one of L.
As MMPs pertencem a classe metalo, dependem de zinco para a sua acao catalitica e sao classificadas em cinco grupos: colagenases (MMP-1
, MMP-8, MMP-13, MMP-18), gelatinases (MMP-2 e MMP-9), estromalisinas (MMP-3, MMP-10, MMP-11), MMPs tipo membrana (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, MMP-25) e outros (MMP-7, MMP-12, MMP-20 e MMP-26) (Tabela 1) (9, 12, 13).
To facilitate the mobility of these cells, an enzyme needed to break down collagen, which is the largest component of the extracellular matrix, called collagenase (matrix metalloproteinases/ MMP), such as MMP-1
, -8, and -13.
According to the company it is a pomegranate flower-derived, two component-based active that not only promotes collagen synthesis but also decreases the breakdown of collagen by inhibiting MMP-1
DEP evokes the secretion of matrix metalloproteinase-1 (MMP-1
) from human bronchial epithelia, which is important because MMP-1
plays a role in tissue remodeling during respiratory disease processes.
The new research shows that in patients with TB, there is an increase in levels of an enzyme called MMP-1
in their lungs.
(12), (14-18), (44), (45) Collected research indicates that berberine can down-regulate the activity of MMP-1
(which also acts against type II collagen and activates MMP-2) and MMP-9, as well as modulating the expression or activity associated with ROS, IL-1[beta], IL-6, NF-[kappa]B, AP-1, TNF-[alpha], and kinase pathways.
Fremont, CA, April 25, 2010 --(PR.com)-- AnaSpec has announced the release of three new MMP recombinant proteins, MMP-1
, MMP-9 and MMP-12.