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Mesenchymal tumors, including MMMTs, endometrial stromal sarcomas, mullerian adenosarcoma, leiomyosarcomas and uterine pleomorphic rhabdomyosarcomas, have been more recently described with tamoxifen use [3,9] and have a poor prognosis.
Histological examination of the endometrial curettage showed a total occupation of a malignant tumor with the characteristics of homologous MMMTs.
There is a very strong association between the tamoxifen treatment and the occurrence of MMMTs of the uterine corpus.
4-6,9-11) MMMTs are sub-divided into homologous and heterologous tumors.
MMMTs of the uterus arise in the endometrium and the epithelial component usually predominates.
FIGO staging of MMMTs of the uterus is the same as for endometrial carcinoma.
Malignant features in epithelial component ruled out adenosarcoma, so the diagnosis of MMMT was confirmed.
The characteristic microscopic features of MMMTs are the admixture of carcinomatous and sarcoma like elements resulting in a biphasic pattern.
Various muscle markers, CD (10), and HER-2/ neu also have been encountered in MMMTs (8).
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- Mmmeri Mouloud