PTEN

(redirected from MMAC1)
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PTEN

A gene on chromosome 10q23.3 which encodes PTEN (phosphatase and tensin homolog), a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase protein, which acts as a tumour suppressor by negatively regulating the AKT/PKB-signalling pathway.
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References in periodicals archive ?
Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10g23.3 that is mutated in multiple advanced cancers.
The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1negative cases.
Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.