ADAM1bca12

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ADAM1bca12

An ADAMs family protein encoded by ADAM12 on chromosome 10q26.3, which has two forms—ADAM12S (short secreted form) and ADAM12L (long membrane-bound form)—generated by alternative splicing. It is synthesized as a proenzyme in which the pro domain maintains the metalloprotease domain in a latent form. After activation, ADAM12’s metalloprotease domain is catalytically active. It is involved in myogenesis, required for myotube formation, expressed largely in mesenchymal cells that give rise to skeletal muscle, bones and viscera, may play a role in osteoblast differentiation and activity, and has been linked to obesity and adipogenic cell proliferation. Secreted ADAM12, which is highly expressed in placental tissues, binds to insulin-like growth factor-binding protein-3 (IGFBP-3).
Activities, ADAM12 Degrades gelatin, collagen IV, fibronectin, IGFBP3, a2-macroglobulin. It interacts with integrin-alpha-9/integrin-beta-1. The cytoplasmic tail of ADAM12 mediates interactions with the nonreceptor protein tyrosine kinase Src through the SH3 domain. It is inhibited by TIMP-3. 
Abnormal expression Haematologic malignancy—e.g., leukaemia, erythroleukemia, lymphoma, and myeloma. It is found in the urine of breast cancer patients; the levels correlate with cancer progression. Likewise, in liver cancer, ADAM12 expression correlates with tumour aggressiveness and progression.
References in periodicals archive ?
is analyzing whether an uncertain tax position meets the MLTN standard.
One deficiency in FIN 48 is the substantial cliff effect of the MLTN standard.
For pass-though entities and tax-exempt not-for-profit organizations, the first step in implementing Topic 740 is to determine if it is MLTN that the pass-through or tax-exempt status would be sustained upon audit.
A new preface sets forth a brief description of the most common tax return reporting standards, ranging from the MLTN standard at the high end of the reporting spectrum (used in many jurisdictions for tax shelters and reportable transactions) to RB at the lower end.
Yet, since the firm does not meet the MLTN threshold for recognition it may not record any benefit for any of the income tax positions under FIN 48.
MLTN requires a higher degree of certainty than the previous RPOS standard.
They were acquired in an M&A transaction, and in the view of the company fail the MLTN test.
137) Marketed opinions without a "no-reliance" disclaimer are covered opinions and cannot be provided unless they reach a MLTN confidence level as to the overall conclusion and as to each significant tax issue.
Management does not believe the MLTN threshold has been met and has accrued a reserve for the entire current tax benefit.
A position meeting the MLTN standard must then be measured to determine the amount that is recorded in the financial statements.
FIN 48 indicates that an enterprise is not required to obtain a third-party tax opinion to demonstrate that it meets the MLTN threshold.
This MLTN standard was greater than the authority level under the accuracy penalties of Sec.