MAP3K11

(redirected from MLK3)
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MAP3K11

An oncogene on chromosome 11q13.1-q13.3 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K11 activates the JUN N-terminal pathway; it is required for serum-stimulated cell proliferation and for mitogen and
cytokine activation of MAPK14/p38, MAPK3/ERK and MAPK8/JNK1, through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. MAP3K11 plays a role in mitogen-stimulated phosphorylation and activation of BRAF; it influences microtubule organisation during the cell cycle, and is expressed in a wide range of benign and malignant tissues.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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References in periodicals archive ?
The 3'UTR of MLK3 was generated by PCR and the luciferase reporter constructs with the miR-138 3'UTR carrying a putative miR-138-binding site into pMiR-report vector were amplified by PCR.
Emodin activated Sirt1/AKT and Wnt/[beta]-catenin signaling pathways by down-regulating MLK3
As shown in the luciferase results, MLK3 was proven to be a target of miR-138 (Figure 7A).
Small G-proteins Rac1 and cdc42 activate ASK1, MLK3, and MLK3 that directly activate MKK3 and MKK6 which phosphorylates p38 on both tyrosine and threonine residue resulting in the activation of p38 pathway [68, 69].
MAPKK kinases that regulate activation of p38 MAPK include kinases (Mlk1, Mlk2, Mlk3, Dlk, and Lzk), Mekk kinases (Mekk1, Mekk2, Mekk3, and Mekk4), Tak1, Ask1, Ask2, and Tpl- (2.20-26) Activation of the MAPKK kinases or MAPKKs occurs downstream from small G proteins whose function is regulated by the guanine exchange factor proteins.