DUSP1

(redirected from MKP1)
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DUSP1

A gene on chromosome 5q34 that encodes dual-specificity phosphatase 1, a protein which dephosphorylates MAP kinase MAPK1/ERK2. DUSP1 downregulates cell proliferation and is thought to play a key role in cellular responses to environmental stress. It is also a less preferred gene symbol for what is now designated as DUSP12, see there.
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The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation.
The MAPK phosphatase 1 (mkp1) mutant of Arabidopsis is more resistant to salinity stress.
In this context, Langenbach and Handschel [98] have reported that "Dexamethasone induces Runx2 expression by FHL2/[beta]-catenin-mediated transcriptional activation and that dexamethasone enhances Runx2 activity by upregulation of TAZ and MKP1. Ascorbic acid leads to the increased secretion of collagen type I (Col1), which in turn leads to increased Col1/[alpha]2[beta]1 integrin-mediated intracellular signaling.
Kuhlman et al., "Knockout of Mkp1 enhances the host inflammatory responses to gram-positive bacteria," The Journal of immunology, vol.