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Glucocorticoid receptor (GR) and mitogen-activated protein kinase phosphatase 1 (MKP-1) expression were detected by polymerase chain reaction and Western blotting (WB).
Thus, we investigated the effects of GLCCI1 deficiency on the GC sensitivity in asthmatic mice model and detected the glucocorticoid receptor (GR), mitogen-activated protein kinase phosphatase 1 (MKP-1) expression, and p38 mitogen-activated protein kinase (MAPK) phosphorylation level in the lung tissue of these mice.
Curcumin inhibited MUC5AC expression via inhibition of p38 MAPK via induction of negative regulator, MKP-1. Thus, our study provides evidence for the anti-inflammatory potential of curcumin in treating NTHi-induced OM by suppressing MUC5AC mucin overproduction.
Antibodies for MUC5AC (sc21701) and MKP-1 (sc-370) were purchased from Santa Cruz Biotechnology.
We also found clear rhythms of MAP kinase phosphatase-1 (Mkp-1) expression in liver.
Through a complex series of experiments, the researchers identified a new location where the vitamin-D receptor appears to bind directly to DNA and activate a gene known as MKP-1. MKP-1 interferes with the inflammatory cascade triggered by LPS, which includes a molecule known as p38, and results in higher levels of IL-6 and TNF-alpha.
Scientists found the MKP-1 gene after analysing brain tissue samples from 21 dead patients who were diagnosed with depression.
Scientists identified the gene, called MKP-1, after analysing brain tissue samples from 21 dead patients who were diagnosed with depression.
Next, they measured mitogen-activated protein kinase phosphatase-1 (MKP-1) and interleukin-10 (IL-10).
Next, they measured mitogen-activated protein kinase phosphatase1 (MKP-1) and interleukin-10 (IL-10.)
While Duman's team found several hundred differences, most striking were levels of mRNA for a particular protein, MKP-1, which inhibits a pathway involved in neural growth and development.
Duman's team found that one gene called MKP-1 was increased more than two-fold in the brain tissues of depressed individuals.
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