KIF23

(redirected from MKLP1)
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KIF23

A gene on chromosome 15q23 that encodes a kinesin-like protein that cross-bridges antiparallel microtubules and drives microtubule movement in the mitotic spindle.
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Confocal microscopy of sea urchin MKLP1 staining in ammonia-activated eggs indicated that this kinesin-related protein started to accumulate in the midzone region of the bipolar, anastral mini-spindles at metaphase (Fig.
Jonathan Scholey (University of California, Davis) for the generous gift of anti-sea urchin MKLP1 antibody, and Louie Kerr (Marine Biological Laboratory) for assistance with confocal fluorescence microscopy.
Abbreviations: CPC, chromosomal passenger complex; CYK-4, cytokinesis gene 4; DAP1, 4',6-diamidino-2-phenylindole; DTT, dithiothreitol; GAP, GTPase-activating protein; INCENP, inner centromere protein; MgcRacGAP, male germ cell Rac GTPase-activating protein; MKLP1, mitotic kinesin-like protein I; Rho, Ras homolog family member; RhoA, Ras homolog family member A; RhoGEF Ect2, Rho guanine nucleotide exchange factor epithelial cell transforming sequence 2.