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Targeted antigens and associated diseases for mitotic patterns Pattern (ICAP) Code Antigen association Disease association Centrosome AC-24 Pericentrin, ninein, Rare in SSc, Cep250, CepllO, Raynaud's enolase phenomenon, infections (viral and mycoplasma) Spindle fibers AC-25 HsEg5 Rare in SjS, SLE, other SARD NuMA-like AC-26 Centrophilin SjS, SLE, other Intracellular AC-27 Aurora kinase B, Rare in SSc, bridge CENP-E, MSA-2, KIF- Raynaud's 14, MKLP-1 phenomenon, malignancy Mitotic AC-28 Modified histone H3, Rare in discoid chromosome coat MCA-1 lupus erythematosus, chronic lymphocytic leukemia, SjS, and polymyalgia rheumatica