EPCAM

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EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
Among the vitamin K2 derivatives, MK-2 (n = 2) showed the greatest cytotoxicity, followed by MK-1 (n = 1) and MK-3 (n = 3).
FM COMNAVSEASYSCOM WASHINGTON DC//05P// MSGID/GENADMIN,USMTF,2007/COMNAV SEASYSCOM WASHINGTON DC// SUBJ/MK-1 LIFE PRESERVER INFLATION ASSEMBLY REPLACEMENT OF// REF/A/MSGID:MSG/NAVSURFWARCENDIV INDIAN HEAD /271803ZNOV2006// REF/B/MSGID:MSG/NAVSURFWARCENDIV INDIAN HEAD/101339ZDEC2007// REF/C/MSGID:DOC/NAVAIR 11-100-1.1CD/// AMPN/REF A IS MESSAGE ANNOUNCING AVAILABILITY OF NEW INFLATION ASSEMBLY FOR USE WITH THE MK-1 LIFE PRESERVER FOR DEPLOYING AIRWINGS.
BASED ON REFS A AND B, THE FOLLOWING GUIDANCE WAS PROVIDED TO THE USERS OF THE MK-1 LIFE PRESERVER:
A NEW CONAX AUTO INFLATOR (MODEL FLU-12, NSN 1377-01-302-2560) WAS APPROVED FOR USE WITH EXISTING MK-1 LIFE PRESERVERS.
THE NEW CONAX INFLATOR IS A NO COST ITEM TO THE SHIPBOARD USER AND IS BEING SUPPLIED TO THE FLEET FROM A DIFFERENT SUPPLY AGENCY THAN THE ONE SUPPLYING THE MK-1 LIFE PRESERVER.
The MK-1 version had a large enclosure, two "tunable" 3-inch ports, and a 250-watt, on-board amplifier.
The MK-1 version, with one port open, would generate so much turbulence down low at really high outputs that it could ruffle your pant legs from four feet away if you stood behind it.
My own Hsu TN1220 topped out at 113 dB and the earlier VTF-3 MK-1 could hit 112.
Normally, to get maximum extension with the MK-3 sub one does the same thing as they did with the MK-1 and MK-2 versions: plug one of the two ports and set the amp-contouring switch for maximum extension.
I frequently visit squadrons that have received the LPU-32/P-the authorized replacement for the Mk-1 float coat for aircraft passengers.
Limited tenders are invited for Direct on line starter type mk-1, direct on line starter, starter type mk-1 1-1.6 amp, starter tpye mk-1 1.5amp to 2.5 amp etc.