EPCAM

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EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).

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References in periodicals archive ?

Among the vitamin K2 derivatives, MK-2 (n = 2) showed the greatest cytotoxicity, followed by MK-1 (n = 1) and MK-3 (n = 3).

Tumor-specificity and type of cell death induced by vitamin K2 derivatives and prenylalcohols

1CD/// AMPN/REF A IS MESSAGE ANNOUNCING AVAILABILITY OF NEW INFLATION ASSEMBLY FOR USE WITH THE MK-1 LIFE PRESERVER FOR DEPLOYING AIRWINGS.

BASED ON REFS A AND B, THE FOLLOWING GUIDANCE WAS PROVIDED TO THE USERS OF THE MK-1 LIFE PRESERVER:

A NEW CONAX AUTO INFLATOR (MODEL FLU-12, NSN 1377-01-302-2560) WAS APPROVED FOR USE WITH EXISTING MK-1 LIFE PRESERVERS.

THE NEW CONAX INFLATOR IS A NO COST ITEM TO THE SHIPBOARD USER AND IS BEING SUPPLIED TO THE FLEET FROM A DIFFERENT SUPPLY AGENCY THAN THE ONE SUPPLYING THE MK-1 LIFE PRESERVER.