demonstrated that most sensitive immunohistochemical stain for a PEComa is HMB45 (92%), followed by Melan-A (72%) and MiTF
(50%) [6, 7].
Botas, "Drosophila Mitf
regulates the V-ATPase and the lysosomal-autophagic pathway," Autophagy, vol.
Raising levels of ALX3 in cells interfered with activity of a gene called Mitf
, a master regulator of pigment production and melanocyte maturation.
A SUMOylation-defective MITF
germline mutation predisposes to melanoma and renal carcinoma.
Glutamate receptors on human melanocytes regulate the expression of MiTF
. Pigment Cell Res 2006;19:58-67.
Microphthalmia transcription factor (MiTF
) staining showed diffuse positive nuclear staining in the tumor (figure 4); vimentin was also diffusely positive but nonspecific.
and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation.
Commonly used markers for mucosal melanoma include S-100, HMB 45, Melan A, tyrosinase and Microphthalmia Transcription Factor (MITF
Recent studies evidenced the correlation between CEACAM1 expressions in melanoma cell lines and melanoma tissue with microphthalmia-associated transcription factor (MITF
UV radiation, which damages the DNA, results in an increase of the production of melanin and blocks the cell cycle through microphthalmia associated transcription factor (MITF
They then performed a transcription factor screening assay and found three transcription factors out of those 10 that are required for melanocytes: SOXIO, MITF
, and PAX3, a combination dubbed SMP3.
For the negative control, additional sections were stained with an antihuman microthalmia transcription factor (MiTF
) antibody (clone D5; Department of Pathology, Johns Hopkins Medical Institutes, Baltimore, MD).