MITF


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MITF

Microphthalmia transcription factor. A helix-loop-helix leucine zipper-type transcription factor encoded by MITF on chromosome 3p14.2-p14.1, which is involved in melanocyte and osteoclast development. MITF controls the DNA damage response, and plays a critical role in melanoma proliferation; its inhibition is associated with G0-G1 growth arrest, and lineage-specific senescence in melanomas.
References in periodicals archive ?
demonstrated that most sensitive immunohistochemical stain for a PEComa is HMB45 (92%), followed by Melan-A (72%) and MiTF (50%) [6, 7].
Botas, "Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway," Autophagy, vol.
Raising levels of ALX3 in cells interfered with activity of a gene called Mitf, a master regulator of pigment production and melanocyte maturation.
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma.
Glutamate receptors on human melanocytes regulate the expression of MiTF. Pigment Cell Res 2006;19:58-67.
Microphthalmia transcription factor (MiTF) staining showed diffuse positive nuclear staining in the tumor (figure 4); vimentin was also diffusely positive but nonspecific.
Commonly used markers for mucosal melanoma include S-100, HMB 45, Melan A, tyrosinase and Microphthalmia Transcription Factor (MITF).
Recent studies evidenced the correlation between CEACAM1 expressions in melanoma cell lines and melanoma tissue with microphthalmia-associated transcription factor (MITF) [45].
UV radiation, which damages the DNA, results in an increase of the production of melanin and blocks the cell cycle through microphthalmia associated transcription factor (MITF).
They then performed a transcription factor screening assay and found three transcription factors out of those 10 that are required for melanocytes: SOXIO, MITF, and PAX3, a combination dubbed SMP3.
For the negative control, additional sections were stained with an antihuman microthalmia transcription factor (MiTF) antibody (clone D5; Department of Pathology, Johns Hopkins Medical Institutes, Baltimore, MD).