[7] first evaluated abnormal expression of miRNAs in the intestinal tissue of UC patients in 2008, finding a specific miRNA expression pattern: three miRNAs (miR192, miR375, and miR422b) were markedly downregulated and eight (miR16, miR21,
miR23a, miR24, miR29a, miR126, miR195, and let7f) notably upregulated in active UC tissues [8].