CCL20

(redirected from MIP3A)

CCL20

A gene on chromosome 2q33-q37 that encodes a chemotactic factor that attracts lymphocytes and neutrophils, but not monocytes. CCL20 inhibits proliferation of myeloid stem cells in colony formation assays, and may be involved in proliferation and activity of mucosal lymphoid tissues (e.g., BALT, MALT, SALT) by attracting lymphocytes and dendritic cells towards epithelial cells.
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Markham, "Fusion of the dendritic cell-targeting chemokine MIP3a to melanoma antigen Gp100 in a therapeutic DNA vaccine significantly enhances immunogenicity and survival in a mouse melanoma model," Journal for Immunotherapy of Cancer, vol.
Stimulation with these ligands has been reported to promote the expression of cytokines and chemokines with roles in immunomodulation and inflammation such as CXCL10 [94], IL-6 [86, 94-97, 100, 101], IL-8 [86, 94-96, 100], CCL5 [95, 96], IL-12 [94, 95, 97], IL-27 [95], IL-23 [95], IL-1[beta] [96], MIP3a [97], TNF[alpha] [94, 97], and CCL2 [97].