CXCL2

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CXCL2

A gene on chromosome 4q13.3 that encodes a chemokine produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is thought to have a haematoregulatory role and suppresses haematopoietic progenitor cell proliferation.
References in periodicals archive ?
The numbers in set B for MIP1 and MIP2 denote the maximum number of subjobs for each job.
The new model, MIP2, that will be explained in Section 3.2 is identical with the GAspLA that will be explained in Section 4.
To achieve equal subjob quantities in MIP2, constraint sets (17) and 18) will be added to the MIP1 that was explained in the previous subsection.
Data for the inflammatory response derived from the concentrations of IL-1[beta] and MIP2 in BALF are presented in Figures 6 and 7, respectively.
In Figures 6B and 7B, the low-dose response data for IL-1[beta] and MIP2 are also presented on logarithmic dose scales, which is to illustrate that sufficiently detailed measurements at low doses provide a better means of identifying the zero-dose response (or offset) than using a rather limited number of sham or control experiments.
To characterize the degree of inflammatory changes in the lung at a molecular level, we analyzed the amount of various proinflammatory cytokines released into the alveolar space: IL1-[beta] and TNF-[alpha], two cytokines commonly produced by activated monocytes, and MIP2 and KC, two potent neutrophil attractants that represent the murine functional homologs to human IL-8.
In Figure 2A, the inverse correlation between primary particle size and inflammatory response, reflected by the PMN influx and MIP2 or IL-1[beta] concentrations in BALF, is presented for the exemplary dose of 20 [micro]g.
CXCR2 ligands, namely, MIP2 (CXCL2) and KC (CXCL2) are the major ligands required for chemotactic signaling of neutrophils into brain abscesses as demonstrated by CXCR2 KO mice studies [92].