CCL20

(redirected from MIP-3a)

CCL20

A gene on chromosome 2q33-q37 that encodes a chemotactic factor that attracts lymphocytes and neutrophils, but not monocytes. CCL20 inhibits proliferation of myeloid stem cells in colony formation assays, and may be involved in proliferation and activity of mucosal lymphoid tissues (e.g., BALT, MALT, SALT) by attracting lymphocytes and dendritic cells towards epithelial cells.
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The chemokines including CCL20 (MIP-3a) may play a role in the pathogenesis of preterm labor [27].
It gives the assumption that MIP-3a and TARC might be involved in the inflammatory process and be potential markers of silent inflammation during pregnancy.
The team also observed that the monkeys treated with glycerol monolaurate lso produced less Mip-3a than the control animals, suggesting that the treatment reduces the immune response that helps HIV to spread.