CLEC4E

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CLEC4E

A gene on chromosome 12p13.31 that encodes a C-type lectin domain protein which acts as a cell surface receptor for an array of ligands, including damaged cells (e.g., SAP130, a nuclear protein released by dying cells), fungi (e.g., alpha-mannose residues on the genus Malassezia) and mycobacteria (e.g., trehalose 6,6’-dimycolate (TDM), a cell wall glycolipid). CLEC4E transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain (FCER1G) and
induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappaB.
References in periodicals archive ?
Tenders are invited for Supply of Item: TLR-2 Antibody, Dectin-1 Antibody, Mincle Antibody
Vance et al., "Mincle activation and the syk/card9 signaling axis Are central to the development of autoimmune disease of the eye," Journal of Immunology, vol.
The macrophage-inducible C-type lectin receptor (Mincle), a Fc[gamma]R-coupled pathogen recognition receptor (PRR) [263, 264], has been reported to contribute to macrophage polarization [265].
It has been reported that macrophage-inducible C-type lectin (Mincle) is activated by endogenous ligands secreted by dead adipocytes and drives ATM migration in the course of CLS organization [31].
Lang, "Stat6-dependent inhibition of mincle expression in mouse and human antigen-presenting cells by the Th2 cytokine IL-4," Frontiers in Immunology, vol.
Among these receptors there are lectin-like recognition molecules, such as CD169 and CD33; also related C-type lectins, such as Dectin-2, Mincle, or DNGR-1; scavenger receptors [5]; and Dectin-1, which is a receptor for fungal beta-glucan [6].
Los receptores de tipo lectina C (CLR) reconocen carbohidratos complejos presentes en bacterias, virus y hongos, e incluyen miembros como dectina-1 y dectina-2 (tambien conocidos como CLEC7A (C-type lectin domain family member A) y CLECF4N (C-type lectin domain family member N), respectivamente; DEC-205 (dendritic and epithelial cells, 205 kDa), MR (receptor de manosa) y Mincle. Los receptores citosolicos tipo ANA helicasa (RLR) incluyen los miembros RIG-I (retinoic acid-induced gene I)y MDA-5 (Melanoma differentiation-associated gene-5).
Recently, the macrophage-inducible C-type lectin (Mincle) was also found to bind to mannan and Candida cells.
Hence, we investigated the ability of TDB, curdlan, and furfurman, which stimulate Mincle, Dectin-1, and Dectin-2, respectively, to elicit both mucosal and systemic immune reactions via several transcription factors (NF-[kappa]B, NFAT, and AP-1) and cellular pathways (cytokine secretion and maturation of dendritic cells).
Mincle, the member of C-type lectin superfamily, is expressed by neutrophils and recognizes trehalose dimycolate (TDM), a cord factor of Mtb.
Inoue, "M1 macrophage triggered by Mincle leads to a deterioration of acute kidney injury," Kidney International, vol.