Vance et al., "Mincle
activation and the syk/card9 signaling axis Are central to the development of autoimmune disease of the eye," Journal of Immunology, vol.
The macrophage-inducible C-type lectin receptor (Mincle
), a Fc[gamma]R-coupled pathogen recognition receptor (PRR) [263, 264], has been reported to contribute to macrophage polarization .
It has been reported that macrophage-inducible C-type lectin (Mincle
) is activated by endogenous ligands secreted by dead adipocytes and drives ATM migration in the course of CLS organization .
Lang, "Stat6-dependent inhibition of mincle
expression in mouse and human antigen-presenting cells by the Th2 cytokine IL-4," Frontiers in Immunology, vol.
Among these receptors there are lectin-like recognition molecules, such as CD169 and CD33; also related C-type lectins, such as Dectin-2, Mincle
, or DNGR-1; scavenger receptors ; and Dectin-1, which is a receptor for fungal beta-glucan .
Recently, the macrophage-inducible C-type lectin (Mincle
) was also found to bind to mannan and Candida cells.
Hence, we investigated the ability of TDB, curdlan, and furfurman, which stimulate Mincle
, Dectin-1, and Dectin-2, respectively, to elicit both mucosal and systemic immune reactions via several transcription factors (NF-[kappa]B, NFAT, and AP-1) and cellular pathways (cytokine secretion and maturation of dendritic cells).
, the member of C-type lectin superfamily, is expressed by neutrophils and recognizes trehalose dimycolate (TDM), a cord factor of Mtb.
Inoue, "M1 macrophage triggered by Mincle
leads to a deterioration of acute kidney injury," Kidney International, vol.