factor X deficiency

(redirected from MIM 227600)

factor X deficiency

An autosomal-recessive condition caused by a mutation on chromosome 13q34, resulting in decreased factor X production.
 
Clinical findings

• Infancy—Severe umbilical cord stump bleeding, prolonged bleeding following circumcision
• Childhood—Recurring nose-bleeds, easy bruising, hemarthroses.
• Ob/Gyn complaints—Menorrhagia, spontaneous first-trimester abortion, postpartum bleeding.
Other complications—Haematuria; excessive bleeding due to surgery or trauma; pseudotumours; intracranial bleeding; bleeding in soft tissues, muscles, and gut.