MICU1


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MICU1

A gene on chromosome 10q22.1 that encodes a key regulator of mitochondrial calcium uptake, which is required for calcium entry into mitochondria. MICU1 may act as a calcium sensor via its EF-hand domains, gating the calcium channel partner activity. MICU1 induces T-helper-1-mediated autoreactivity, which is accompanied by release of IFNG.
References in periodicals archive ?
They then developed adult mice in which MICU1 was removed only in the liver, an organ that can normally regenerate itself when damaged.
Rather strengthening both the sophisticated gatekeeping as well as the calcium signaling function of MICU1, might be sensible," he says.
MICU1, mitochondrial calcium uptake 1; MICU2, mitochondrial calcium uptake 2; MCUR1, mitochondrial calcium uniporter regulator 1; EMRE, essential mitochondrial calcium uniporter regulator.
Cardenas et al., "MICU1 is an essential gatekeeper for mcu-mediated mitochondrial [Ca.sup.2+] uptake that regulates cell survival," Cell, vol.