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They then developed adult mice in which MICU1 was removed only in the liver, an organ that can normally regenerate itself when damaged.
Rather strengthening both the sophisticated gatekeeping as well as the calcium signaling function of MICU1, might be sensible," he says.
MICU1, mitochondrial calcium uptake 1; MICU2, mitochondrial calcium uptake 2; MCUR1, mitochondrial calcium uniporter regulator 1; EMRE, essential mitochondrial calcium uniporter regulator.
Cardenas et al., "MICU1 is an essential gatekeeper for mcu-mediated mitochondrial [Ca.sup.2+] uptake that regulates cell survival," Cell, vol.