Also found in: Dictionary, Encyclopedia.
MICU1A gene on chromosome 10q22.1 that encodes a key regulator of mitochondrial calcium uptake, which is required for calcium entry into mitochondria. MICU1 may act as a calcium sensor via its EF-hand domains, gating the calcium channel partner activity. MICU1 induces T-helper-1-mediated autoreactivity, which is accompanied by release of IFNG.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.