MICAL2

MICAL2

A gene on chromosome 11p15.3 that encodes a monoxygenase which promotes depolymerisation of F-actin by mediating oxidation of specific methionine residues on actin, preventing repolymerisation.
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Genes included are: trafficking protein particle complex 8 (TRAPPC8) for HMC and apolipoprotein B antigen (APOB), ataxia telangiectasia mutated (ATM), coiled-coil domain containing 88A (CCDC88A; transcript variant 1), complement factor H (CFH), collagen, type XXVIII, alpha 1 (COL28A1), glycoprotein IX (GP9 [platelet]), ligase IV (LIG4, DNA, ATP-dependent), melanoma inhibitory activity family, member 3 (MIA3), microtubule associated monooxygenase, calponin and LIM domain containing 2 (MICAL2), RE1silencing transcription factor (REST), small nuclear RNA activating complex, polypeptide 1 (SNAPC1, 43 kDa; transcript variant 1), TNF receptor-associated factor 1 (TRAF1), UTP18 small subunit processome component homolog (UTP18 [yeast]), and LOC428119 (uncharacterized protein) for LMC.
Molecules, such as APOB, ATM, MIA3, MICAL2, REST, TRAF1, UTP18, TRAPPC8, CCDC88A, and SNAPC1 in the network were shown to bind directly to UBC (ubiquitin C) by proteomic analyses of ubiquitylated proteomes [12-15], suggesting that the various cellular functions including protein degradation by ubiquitylation may play a role for the expression of muscle color in chickens though the specific roles of each factor in regulating muscle color development need further investigations.