values 0.20 mg/mL (2.8 mM) in this study were comparable with a variation towards higher side, but broth dilution assay had been used for determination of MIC.
However, further detailed pharmacodynamic studies of amoxicillin in Lohi sheep and Beetal goats are required to identify an actual as opposed to an assumed MIC90
for confirming the dose by generating sufficient data from field isolates in future studies before issuing final recommendations.
of 178 isolates was compared by Cooper et al and found it to be 0.06ug/ml in 2001.
In 217 strains of CRAB from different patients, [MIC.sub.50] and MIC90
values were 0.5 and 1mg/L, respectively.
At each time peak, plasma drug concentrations were at or above the least inhibitory concentration (MIC90
), whereas free drugs were cleared from the circulation within 12 hrs of oral administration .
of cefovecin against Staphylococcus intermedius was 0.25 microg/ml, for Escherichia col was 1.0 microg/ml and 0.06 microg/ml for Pasteurella multocida .
Table I.- Values of MIC50 MIC90
MIC range and mode for clinical strains.
Assessment of the Minimum Inhibitory Concentration (MIC90
Table 1: Effect of medium pH levels on MICrange and MIC90
and the susceptibility percentage (Susc.%) of some antibiotics against B.
The MIC50 and MIC90
of these isolates were found to be respectively 0.094[micro]g/ml and 0.125[micro]g/ml.
Antibiotic susceptibility in Kingella species isolates MIC50 MIC90
Amoxicillin 0.064 0.5 Cefotaxime 0.094 0.125 Ciprofloxacin 0.047 0.064 Meropenem 0.064 0.125 Trimethoprim-sulfamethoxazole 0.02 >32 Range Amoxicillin [less than or equal to] 0.016-0.5 Cefotaxime 0.032-0.125 Ciprofloxacin 0.016-0.064 Meropenem 0.008-0.125 Trimethoprim-sulfamethoxazole [less than or equal to] 0.02->32 % Susceptible K.
Many studies have found that most isolates are resistant to ampicillin [7, 9, 15-17, 26, 29, 51] with an MIC90
of 32mg/mL  and penicillin [9, 29], but susceptible to third- and fourth-generation cephalosporins, quinolones, aminoglycosides, and carbapenems [4,15-17, 38, 61].