EPCAM

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EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
Mustang (a tad-type cultivar), and MIC18 (a dwarf, turf-type cultivar) under well-watered conditions.
In the second study, sod plugs from established MIC18 and Kentucky 31, each 30 cm in diam.
However, RLD of MIC18 was lower than that of Mustang at 30 to 60 and 60 to 90 cm.
Root dry weight was reduced by 17, 12, 16, and 19% for MIC18 and by 12, 8, 8, and 15% for Kentucky-31 at 7, 14.
MIC18 had significantly higher SRL values than Kentucky-31 under well-watered conditions and at 28 d of soil drying (Fig.
In our study, the extent of root hair development at the basal 5 cm of nodal roots was similar for MIC18 and Kentucky-31 under either well-watered or drying conditions.
Root water potential was lower at 7, 14, and 21 d of drying than that under well-watered conditions for both Kentucky-31 and MIC18 (Table 2).
root]) and turgor pressure in response to soil drought stress for Kentucky-31 and MIC18.
Severe cortical cell collapse, as evidenced by air space formation, was observed at 14 and 28 d of dry down for both cultivars, causing root shrinkage of a similar extent for Kentucky-31 and MIC18 (Fig.
Under drying conditions, considerable electrolyte leakage occurred from roots of both Kentucky-31 and MIC18, increasing with duration of dry down (Fig.