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Minimum Information about a Microarray Experiment. The non plus minimum needed to enable the interpretation of the results of a microarray experiment unambiguously and reproduce it
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Gene Expression Specifications: Another objective of MIAME was to guide the development of microarray databases and data management software.
Other than the generally accepted MIAME convention, there is little standardization for reporting orthogonal data relevant to interpretation of microarray results (e.g., pathology results or biochemical assay data), nor are developing standards for reporting data from nonclinical safety studies widely accepted.
Indeed, we already have good guidelines for many aspects of reporting, including both MIAME (2) and REMARK (reporting recommendations for tumor marker prognostic studies) (9).
To assess the current level of MIAME compliance in miRNA array studies, I reviewed articles that reported array-based miRNA profiling in the 4 journals that published the largest number of such studies during a 10-month period in 2011-2012.
Minimum information about a microarray experiment (MIAME)--toward standards for microarray data.
Given that the microarray community developed the MIAME ("minimal information about a microarray experiment") criteria and the proteomics community followed suit with MIAPE ("minimal information about a proteomics experiment"), it is surely time for a full fledged MIABA ("minimal information about bioinformatics analysis") effort.
Consequently, the international MGED Society proposed standards for publication (Nature 2002) that were designed to clarify the MIAME guidelines (Brazma et al.
To this end, the Minimum Information about a Microarray Experiment (MIAME) guidelines (Brazma et al.
For markers from high-throughput studies, the MIAME (Minimum Information about a Microarray Experiment) guideline should be considered.
MIAME (Minimum information About a Microarray Experiment)-compliant microarray data for the three independent replicate studies are available as supplementary information and have been submitted to the Gene Expression Omnibus (GEO) database (http://www.ncbi.nlm.nih.gov/geol).
Authors should continue to take primary responsibility for ensuring that all data collected and analyzed in their experiments adhere to the MIAME (Minimum Information About a Microarray Experiment; http://www.mged.org/ Workgroups/MIAME/miame.html) guidelines and continue to use the MIAME checklist (http://www.mged.org/ Workgroups/MIAME/miame_checklist.
There are numerous significant challenges in generating and sharing validated data obtained from gene expression analysis systems, including sample preparation and storage and the type and extent of data that are necessary to describe any microarray experiment, as outlined by the MIAME (Minimal Information About Microarray Experiments) Conference (7).